Evidence map›Paper›PMID 35052345›Full record

ArticleGenes2021

Genetic Dissection of Temperament Personality Traits in Italian Isolates.

Maria Pina Concas, Alessandra Minelli, Susanna Aere, Anna Morgan, Paola Tesolin, Paolo Gasparini, Massimo Gennarelli, Giorgia Girotto

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Maria Pina ConcasInstitute for Maternal and Child Health-IRCCS "Burlo Garofolo", 34127 Trieste, Italy.ORCID 0000-0003-3598-2537
Alessandra MinelliDepartment of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy.ORCID 0000-0002-9463-7808
Susanna AereDepartment of Medicine, Surgery and Health Sciences, University of Trieste, 34139 Trieste, Italy.
Anna MorganInstitute for Maternal and Child Health-IRCCS "Burlo Garofolo", 34127 Trieste, Italy.ORCID 0000-0001-6290-445X
Paola TesolinDepartment of Medicine, Surgery and Health Sciences, University of Trieste, 34139 Trieste, Italy.ORCID 0000-0002-5238-6422
Paolo GaspariniInstitute for Maternal and Child Health-IRCCS "Burlo Garofolo", 34127 Trieste, Italy.
Massimo GennarelliDepartment of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy.
Giorgia GirottoInstitute for Maternal and Child Health-IRCCS "Burlo Garofolo", 34127 Trieste, Italy.ORCID 0000-0003-4507-6589
University of Trieste · ITCentro San Giovanni di Dio Fatebenefratelli · ITIRCCS Materno Infantile Burlo Garofolo · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human personality (i.e., temperament and character) is a complex trait related to mental health, influenced by genetic and environmental factors. Despite the efforts performed during the past decades, its genetic background is only just beginning to be identified. With the aim of dissecting the genetic basis of temperament, we performed a Genome-Wide Association Study (GWAS) on Cloninger's Temperament and Character Inventory in 587 individuals belonging to different Italian genetic isolates. Data analysis led to the identification of four new genes associated with different temperament scales, such as Novelty Seeking (NS), Harm Avoidance (HA), and Reward Dependence (RD). In detail, we identified suggestive and significant associations between:

Indexed as

Adaptor Proteins, Signal TransducingAdolescentAdultAgedAged, 80 and overCalcitonin Gene-Related PeptideCohort StudiesFemaleGenome-Wide Association StudyGuanylate KinasesHumansItalyMaleMiddle AgedNerve Tissue ProteinsPersonalityAdaptor Proteins, Signal TransducingBTBD3 protein, humanCALCB protein, humanCalcitonin Gene-Related PeptideGuanylate KinasesMAGI2 protein, humanNerve Tissue Proteinsparkin proteinUbiquitin-Protein LigasesBTBD3CALCBgenome-wide association studiesMAGI2PARK2temperament scales

Identifiers

PMID35052345
PMCPMC8774962
OpenAlexW4200445660

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.