Evidence map›Paper›PMID 35051622›Full record

ArticleJournal of cardiac failure2022

Epidemiology of Acute Heart Failure in Critically Ill Patients With COVID-19: An Analysis From the Critical Care Cardiology Trials Network.

David D Berg, Carlos L Alviar, Ankeet S Bhatt, Vivian M Baird-Zars, Christopher F Barnett, Lori B Daniels, Andrew P Defilippis, Antonio Fagundes, Praneeth Katrapati, Benjamin B Kenigsberg and 12 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiac failure, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Critical Care Cardiology Trials Network (CCCTN): a cohort profile.European heart journal. Quality of care & clinical outcomes · 2022
    Article
  6. COVID-19 Pandemic and Cardiovascular Diseases: Lessons and Prospects.Herald of the Russian Academy of Sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 8 institutions in 1 country.

David D BergLevine Cardiac Intensive Care Unit, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Carlos L AlviarThe Leon H. Charney Division of Cardiovascular Medicine, New York University Langone Medical Center, New York, New York.
Ankeet S BhattLevine Cardiac Intensive Care Unit, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Vivian M Baird-ZarsLevine Cardiac Intensive Care Unit, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Christopher F BarnettDivision of Cardiology, Department of Medicine, University of California San Francisco, San Francisco, California; Medstar Heart and Vascular Institute, Medstar Washington Hospital Center, Washington, D.C.
Lori B DanielsDivision of Cardiovascular Medicine, Department of Medicine, University of California San Diego, La Jolla, California.
Andrew P DefilippisDivision of Cardiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Antonio FagundesLevine Cardiac Intensive Care Unit, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Praneeth KatrapatiDivision of Cardiovascular Medicine, Department of Medicine, University of Louisville, Louisville, Kentucky.
Benjamin B KenigsbergMedstar Heart and Vascular Institute, Medstar Washington Hospital Center, Washington, D.C.
Jianping GuoLevine Cardiac Intensive Care Unit, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Norma KellerThe Leon H. Charney Division of Cardiovascular Medicine, New York University Langone Medical Center, New York, New York.
Mathew S LopesLevine Cardiac Intensive Care Unit, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Anika ModyDivision of Cardiovascular Medicine, Department of Medicine, University of California San Diego, La Jolla, California.
Alexander I PapolosMedstar Heart and Vascular Institute, Medstar Washington Hospital Center, Washington, D.C.
Nicholas PhreanerDivision of Cardiovascular Medicine, Department of Medicine, University of California San Diego, La Jolla, California.
Romteen SedighiDivision of Cardiovascular Medicine, Department of Medicine, University of California San Diego, La Jolla, California.
Shashank S SinhaInova Heart and Vascular Institute, Inova Fairfax Medical Center, Falls Church, Virginia.
Sandeep ToomuDivision of Cardiovascular Medicine, Department of Medicine, University of California San Diego, La Jolla, California.
Anubodh S VarshneyLevine Cardiac Intensive Care Unit, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
David A MorrowLevine Cardiac Intensive Care Unit, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address: dberg1@bwh.harvard.edu.
Erin A BohulaLevine Cardiac Intensive Care Unit, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Brigham and Women's Hospital · USUniversity of California San Diego · USMedStar Heart & Vascular Institute · USNYU Langone Health · USInova Fairfax Hospital · USUniversity of California, San Francisco · USUniversity of Louisville · USVanderbilt University Medical Center · US

Funding

The Harvard Clinical and Translational Science CenterUL1TR002541 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2018 to 2022
$93.0M
TRAINING PROGRAM IN CARDIOVASCULAR RESEARCHT32HL007604 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MARK W FEINBERG · 1985 to 2026
$19.0M
NCATS NIH HHS UL1 TR002541NHLBI NIH HHS T32 HL007604
6 · The paper itself

Abstract

backgroundAcute heart failure (HF) is an important complication of coronavirus disease 2019 (COVID-19) and has been hypothesized to relate to inflammatory activation.

methodsWe evaluated consecutive intensive care unit (ICU) admissions for COVID-19 across 6 centers in the Critical Care Cardiology Trials Network, identifying patients with vs without acute HF. Acute HF was subclassified as de novo vs acute-on-chronic, based on the absence or presence of prior HF. Clinical features, biomarker profiles and outcomes were compared.

resultsOf 901 admissions to an ICU due to COVID-19, 80 (8.9%) had acute HF, including 18 (2.0%) with classic cardiogenic shock (CS) and 37 (4.1%) with vasodilatory CS. The majority (n = 45) were de novo HF presentations. Compared to patients without acute HF, those with acute HF had higher cardiac troponin and natriuretic peptide levels and similar inflammatory biomarkers; patients with de novo HF had the highest cardiac troponin levels. Notably, among patients critically ill with COVID-19, illness severity (median Sequential Organ Failure Assessment, 8 [IQR, 5-10] vs 6 [4-9]; P = 0.025) and mortality rates (43.8% vs 32.4%; P = 0.040) were modestly higher in patients with vs those without acute HF.

conclusionsAmong patients critically ill with COVID-19, acute HF is distinguished more by biomarkers of myocardial injury and hemodynamic stress than by biomarkers of inflammation.

Indexed as

CardiologyCOVID-19Heart FailureBiomarkersCritical CareCritical IllnessHospital MortalityHumansIntensive Care UnitsShock, CardiogenicTroponinBiomarkersTroponinbiomarkersCOVID-19heart failure

Identifiers

PMID35051622
PMCPMC8762923
OpenAlexW4206349843

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.