ArticleCell2022
Transmission from vaccinated individuals in a large SARS-CoV-2 Delta variant outbreak.
Abstract read
In one paragraph
Article in Cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed.
- Induction of mucosal immune responses against SARS-CoV-2: a heterologous intramuscular mRNA-LNP prime/pulmonary recombinant subunit pull vaccination strategy.Scientific reports · 2026Article
- Integrated framework to study genomic surveillance of selective sweeps in multivariants dynamics.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Geospatial and demographic patterns of SARS-CoV-2 spread in Massachusetts from over 130,000 genomes.medRxiv : the preprint server for health sciences · 2025Article
- Article
- Signatures of transmission in within-host Mycobacterium tuberculosis complex variation: a retrospective genomic epidemiology study.The Lancet. Microbe · 2025Article
- A Dual-Adjuvanted Parenteral-Intranasal Subunit Nanovaccine generates Robust Systemic and Mucosal Immunity Against SARS-CoV-2 in Mice.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Impact of a large-scale event on SARS-CoV-2 cases and hospitalizations in the Netherlands, carnival seasons 2022 and 2023.Public health in practice (Oxford, England) · 2024Article
- The WHO Algorithm for Causality Assessment of Adverse Effects Following Immunization with Genetic-Based Anti-COVID-19 Vaccines: Pitfalls and Suggestions for Improvement.Journal of clinical medicine · 2024Article
- Polyphonia: detecting inter-sample contamination in viral genomic sequencing data.Bioinformatics (Oxford, England) · 2024Article
- Insights from an observational translational research program during the COVID-19 pandemic: Four years of experience.Vaccine · 2024Observational
- Intranasal vaccination with an NDV-vectored SARS-CoV-2 vaccine protects against Delta and Omicron challenges.NPJ vaccines · 2024Article
- Durable immunity to SARS-CoV-2 in both lower and upper airways achieved with a gorilla adenovirus (GRAd) S-2P vaccine in non-human primates.bioRxiv : the preprint server for biology · 2023Article
- Inferring bacterial transmission dynamics using deep sequencing genomic surveillance data.Nature communications · 2023Article
- Protection against Severe Illness versus Immunity-Redefining Vaccine Effectiveness in the Aftermath of COVID-19.Microorganisms · 2023Review
- Intranasal or airborne transmission-mediated delivery of an attenuated SARS-CoV-2 protects Syrian hamsters against new variants.Nature communications · 2023Article
- Retrospective, Observational Studies for Estimating Vaccine Effects on the Secondary Attack Rate of SARS-CoV-2.American journal of epidemiology · 2023Observational
- Impact of SARS-CoV-2 infection and COVID-19 on patients with inborn errors of immunity.The Journal of allergy and clinical immunology · 2023Review
- Challenges in Harnessing Shared Within-Host Severe Acute Respiratory Syndrome Coronavirus 2 Variation for Transmission Inference.Open forum infectious diseases · 2023Article
- SARS-CoV-2 transmission dynamics in bars, restaurants, and nightclubs.Frontiers in microbiology · 2023Article
- Do we need nasal vaccines against COVID 19 to suppress the transmission of infections?Microbial biotechnology · 2023Article
Corrections and comments
- Update of
Authors and funding
80 authors.
Katherine J SiddleBroad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address: kjsiddle@broadinstitute.org.
Lydia A KrasilnikovaBroad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.
Gage K MorenoBroad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Stephen F SchaffnerBroad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA 02115, USA.
Johanna VostokMassachusetts Department of Public Health, Boston, MA 02199, USA.
Nicholas A FitzgeraldBroad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Jacob E LemieuxBroad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA 02114, USA.
Nikolaos BarkasBroad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Christine LorethBroad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Ivan SpechtBroad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Faculty of Arts and Sciences, Harvard University, Cambridge, MA 02138, USA.
Christopher H Tomkins-TinchBroad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.
Jillian S PaullBroad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.
Beau SchaefferDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA 02115, USA; Center for Communicable Disease Dynamics, Department of Epidemiology, Harvard T. H. Chan School of Public Health, Harvard University, Boston, MA 02115, USA.
Bradford P TaylorDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA 02115, USA; Center for Communicable Disease Dynamics, Department of Epidemiology, Harvard T. H. Chan School of Public Health, Harvard University, Boston, MA 02115, USA.
Bryn LoftnessBroad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Hillary JohnsonMassachusetts Department of Public Health, Boston, MA 02199, USA.
Petra L SchubertMassachusetts Department of Public Health, Boston, MA 02199, USA.
Hanna M ShephardMassachusetts Department of Public Health, Boston, MA 02199, USA; Applied Epidemiology Fellowship, Council of State and Territorial Epidemiologists, Atlanta, GA 30345, USA.
Matthew DoucetteMassachusetts Department of Public Health, Boston, MA 02199, USA.
Timelia FinkMassachusetts Department of Public Health, Boston, MA 02199, USA.
Andrew S LangMassachusetts Department of Public Health, Boston, MA 02199, USA.
Stephanie BaezMassachusetts Department of Public Health, Boston, MA 02199, USA.
John BeauchampMassachusetts Department of Public Health, Boston, MA 02199, USA.
Scott HenniganMassachusetts Department of Public Health, Boston, MA 02199, USA.
Erika BuzbyMassachusetts Department of Public Health, Boston, MA 02199, USA.
Stephanie AshMassachusetts Department of Public Health, Boston, MA 02199, USA.
Jessica BrownMassachusetts Department of Public Health, Boston, MA 02199, USA.
Selina ClancyMassachusetts Department of Public Health, Boston, MA 02199, USA.
Seana CofskyMassachusetts Department of Public Health, Boston, MA 02199, USA.
Luc GagneMassachusetts Department of Public Health, Boston, MA 02199, USA.
Joshua HallMassachusetts Department of Public Health, Boston, MA 02199, USA.
Rachel HarringtonMassachusetts Department of Public Health, Boston, MA 02199, USA.
Gabrielle L GionetBroad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Katherine C DeRuffBroad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Megan E VodzakBroad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Gordon C AdamsBroad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Sabrina T DobbinsBroad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Sarah D SlackBroad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Steven K ReillyBroad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Lisa M AndersonBroad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Michelle C CipicchioBroad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Matthew T DeFeliceBroad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Jonna L GrimsbyBroad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Scott E AndersonBroad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Brendan S BlumenstielBroad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
James C MeldrimBroad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Heather M RookeBroad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Gina VicenteBroad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Natasha L SmithBroad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Katelyn S MesserBroad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Faye L ReaganBroad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Zoe M MandeseBroad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Matthew D LeeBroad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Marianne C RayBroad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Marissa E FisherBroad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Maesha A UlcenaBroad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Corey M NoletBroad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Sean E EnglishBroad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Katie L LarkinBroad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Kyle VernestBroad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Sushma ChaluvadiBroad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Deirdre ArvidsonBarnstable County Department of Health and the Environment, Barnstable, MA 02630, USA.
Maurice MelchionoBarnstable County Department of Health and the Environment, Barnstable, MA 02630, USA.
Theresa CovellBarnstable County Department of Health and the Environment, Barnstable, MA 02630, USA.
Vaira HarikBarnstable County Department of Human Services, Barnstable, MA 02630, USA.
Taylor Brock-FisherCommunity Tracing Collaborative, Commonwealth of Massachusetts, Boston, MA 02199, USA.
Molly DunnCommunity Tracing Collaborative, Commonwealth of Massachusetts, Boston, MA 02199, USA.
Amanda KearnsCommunity Tracing Collaborative, Commonwealth of Massachusetts, Boston, MA 02199, USA.
William P HanageDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA 02115, USA; Center for Communicable Disease Dynamics, Department of Epidemiology, Harvard T. H. Chan School of Public Health, Harvard University, Boston, MA 02115, USA.
Clare BernardBroad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Anthony PhilippakisBroad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Niall J LennonBroad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Stacey B GabrielBroad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Glen R GallagherMassachusetts Department of Public Health, Boston, MA 02199, USA.
Sandra SmoleMassachusetts Department of Public Health, Boston, MA 02199, USA.
Lawrence C MadoffMassachusetts Department of Public Health, Boston, MA 02199, USA.
Catherine M BrownMassachusetts Department of Public Health, Boston, MA 02199, USA.
Daniel J ParkBroad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Bronwyn L MacInnisBroad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA 02115, USA; Massachusetts Consortium for Pathogen Readiness, Boston, MA 02115, USA. Electronic address: bronwyn@broadinstitute.org.
Pardis C SabetiBroad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA 02115, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA; Massachusetts Consortium for Pathogen Readiness, Boston, MA 02115, USA.
Funding
Viral Genomics: evolution, spread, and host interactionsU19AI110818 · NIAID · BROAD INSTITUTE, INC. · PI NEAFSEY, DANIEL E · 2014 to 2024
$66.5MWest African Emerging Infectious Disease Research Center (WA-EIDRC)U01AI151812 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI ANDERSEN, KRISTIAN GRAUGAARD, GARRY, ROBERT F · 2020 to 2024
$13.2MComprehensive Characterization of Adaptive Regulatory Variation Linked to Human DiseaseR00HG010669 · NHGRI · YALE UNIVERSITY · PI REILLY, STEVEN K. · 2021 to 2023
$737kComprehensive Characterization of Adaptive Regulatory Variation Linked to Human DiseaseK99HG010669 · NHGRI · BROAD INSTITUTE, INC. · PI REILLY, STEVEN K. · 2019 to 2020
$250kNHGRI NIH HHS K99 HG010669NHGRI NIH HHS R00 HG010669NIAID NIH HHS U01 AI151812NIAID NIH HHS U19 AI110818
Abstract
An outbreak of over 1,000 COVID-19 cases in Provincetown, Massachusetts (MA), in July 2021-the first large outbreak mostly in vaccinated individuals in the US-prompted a comprehensive public health response, motivating changes to national masking recommendations and raising questions about infection and transmission among vaccinated individuals. To address these questions, we combined viral genomic and epidemiological data from 467 individuals, including 40% of outbreak-associated cases. The Delta variant accounted for 99% of cases in this dataset; it was introduced from at least 40 sources, but 83% of cases derived from a single source, likely through transmission across multiple settings over a short time rather than a single event. Genomic and epidemiological data supported multiple transmissions of Delta from and between fully vaccinated individuals. However, despite its magnitude, the outbreak had limited onward impact in MA and the US overall, likely due to high vaccination rates and a robust public health response.
Indexed as
AdolescentAdultAgedAged, 80 and overChildChild, PreschoolContact TracingCOVID-19Disease OutbreaksFemaleGenome, ViralHumansInfantInfant, NewbornMaleMassachusettscontact tracingDeltagenomicsSARS-CoV-2transmissionvaccination
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.