Evidence map›Paper›PMID 35051366›Full record

ArticleStructure (London, England : 1993)2022

Compressed sensing for electron cryotomography and high-resolution subtomogram averaging of biological specimens.

Jan Böhning, Tanmay A M Bharat, Sean M Collins

Open access · hybridAbstract read
In one paragraph

Article in Structure (London, England : 1993), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Charting the molecular landscape of the cell.Structure (London, England : 1993) · 2023
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Jan BöhningSir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK.
Tanmay A M BharatSir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK; Structural Studies Division, MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK. Electronic address: tanmay.bharat@path.ox.ac.uk.
Sean M CollinsSchool of Chemical and Process Engineering & School of Chemistry, University of Leeds, Leeds LS2 9JT, UK. Electronic address: s.m.collins@leeds.ac.uk.
MRC Laboratory of Molecular Biology · GBUniversity of Leeds · GBUniversity of Oxford · GB

Funding

Medical Research Council MR/K501256/1Medical Research Council MR/N013468/1Wellcome TrustWellcome Trust 202231/Z/16/Z
6 · The paper itself

Abstract

Cryoelectron tomography (cryo-ET) and subtomogram averaging (STA) allow direct visualization and structural studies of biological macromolecules in their native cellular environment, in situ. Often, low signal-to-noise ratios in tomograms, low particle abundance within the cell, and low throughput in typical cryo-ET workflows severely limit the obtainable structural information. To help mitigate these limitations, here we apply a compressed sensing approach using 3D second-order total variation (CS-TV

Indexed as

ElectronsImage Processing, Computer-AssistedCryoelectron MicroscopyElectron Microscope TomographyMacromolecular SubstancesSignal-To-Noise RatioMacromolecular Substancescompressed sensingcryo-electron microscopycryo-EMcryo-ETelectron cryomicroscopyimage processingin situ structural biologysubtomogram averaging

Identifiers

PMID35051366
PMCPMC8919266
OpenAlexW4205101093

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.