Trial reportEuropean heart journal2022
Effect of a multi-domain lifestyle intervention on cardiovascular risk in older people: the FINGER trial.
Trial report in European heart journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01041989 (Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability), which is not on this map. Cited by 44 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability
Who cites it
44 citing papers in PubMed, 3 syntheses or guidelines pooled it, 81 citations in OpenAlex.
- Lifestyle scores and their potential to estimate the risk of multiple non-communicable disease-related endpoints: a systematic review.BMC public health · 2025Pooled it
- Digital versus nondigital behavioral interventions on cardiovascular risk reduction: systematic review and meta-analysis.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2025Pooled it
- European stroke organisation (ESO) guideline on cerebral small vessel disease, part 2, lacunar ischaemic stroke.European stroke journal · 2024Guideline
- Cardiovascular and glucose-lowering medication use among older adults: results from 9-year follow-up of the FINGER trial.European geriatric medicine · 2026Trial
- The effect of educational intervention on the lifestyle changes of elderly people with diabetes.BMC endocrine disorders · 2026Trial
- Efficacy of a multidomain intervention in older adults with vascular risks: The Japan-Multimodal Intervention Trial for the Prevention of Dementia (J-MINT).Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Trial
- Impact of a nurse-led multidomain intervention on intrinsic capacity among community-dwelling older adults in China: a cluster randomized trial.BMC public health · 2025Trial
- Trial
- A digitally supported multimodal lifestyle program to promote brain health among older adults (the LETHE randomized controlled feasibility trial): study design, progress, and first results.Alzheimer's research & therapy · 2024Trial
- Trial
- Effects of intensive lifestyle changes on the progression of mild cognitive impairment or early dementia due to Alzheimer's disease: a randomized, controlled clinical trial.Alzheimer's research & therapy · 2024Trial
- Integrating a multimodal lifestyle intervention with medical food in prodromal Alzheimer's disease: the MIND-ADAlzheimer's research & therapy · 2024Trial
- Long-term Impact of a 10-Year Intensive Lifestyle Intervention on a Deficit Accumulation Frailty Index: Action for Health in Diabetes Trial.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Trial
- Physical Performance Moderates the Association Between Age and Executive Function in Older Adults at Elevated Risk of Dementia: Cross-Sectional Analysis From the CITA GO-ON Trial.Journal of cachexia, sarcopenia and muscle · 2026Article
- Programmatic readiness and health literacy predict the adoption of multidomain dementia prevention: a nationwide survey of Japanese municipalities.BMC public health · 2026Article
- Prevention of dementia using mobile phone applications (PRODEMOS) - a health-economic cost-utility analysis in people aged 55-75 years with low socio-economic status.The journal of prevention of Alzheimer's disease · 2026Article
- Associations between self-reported change in lifestyle behaviors and brain health: Findings from the Healthy Brain Initiative.Journal of Alzheimer's disease : JAD · 2026Article
- Lifestyle behaviors and health-related quality of life: a comparative analysis of older and non-older adults.Archives of public health = Archives belges de sante publique · 2026Article
- Global Burden of Cardiovascular Disease: What Should Be Expected in the Next 25 Years?Current cardiology reports · 2026Review
- REMINDER program: a randomized controlled trial protocol of a neuropsychological intervention for lifestyle modification in older adults at risk of dementia.BMC geriatrics · 2025Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsJoint prevention of cardiovascular disease (CVD) and dementia could reduce the burden of both conditions. The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) demonstrated a beneficial effect on cognition (primary outcome) and we assessed the effect of this lifestyle intervention on incident CVD (pre-specified secondary outcome). METHODS AND
resultsFINGER enrolled 1259 individuals aged 60-77 years (ClinicalTrials.gov NCT01041989). They were randomized (1:1) to a 2-year multi-domain intervention with diet, physical and cognitive activity, and vascular monitoring (n = 631), or general health advice (n = 628). National registries provided data on CVD including stroke, transient ischaemic attack (TIA), or coronary heart event. During an average of 7.4 years, 229 participants (18%) had at least one CVD diagnosis: 107 in the intervention group and 122 in the control group. The incidence of cerebrovascular events was lower in the intervention than the control group: hazard ratio (HR) for combined stroke/TIA was 0.71 [95% confidence interval (CI): 0.51-0.99] after adjusting for background characteristics. Hazard ratio for coronary events was 0.84 (CI: 0.56-1.26) and total CVD events 0.80 (95% CI: 0.61-1.04). Among those with history of CVD (n = 145), the incidence of both total CVD events (HR: 0.50, 95% CI: 0.28-0.90) and stroke/TIA (HR: 0.40, 95% CI: 0.20-0.81) was lower in the intervention than the control group.
conclusionA 2-year multi-domain lifestyle intervention among older adults was effective in preventing cerebrovascular events and also total CVD events among those who had history of CVD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.