ArticlePloS one2022
Knee osteoarthritis alters peri-articular knee muscle strategies during gait.
Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Effectiveness of manual therapy targeting hamstring tightness in knee osteoarthritis: a systematic review of rehabilitation outcomes.Frontiers in medicine · 2026Pooled it
- The use of tensiomyography in older adults: a systematic review.Frontiers in physiology · 2023Pooled it
- Association of dynapenic abdominal obesity with prevalence and incidence of symptomatic knee osteoarthritis among the middle-aged and older Chinese.Aging clinical and experimental research · 2026Article
- Changes in lower limb muscle strength and corresponding gait changes following hip fractures in older adults: a narrative review.Frontiers in medicine · 2026Review
- Predicting joint loading in Asian overweight and obese females with flexible flatfoot: a regression analysis of anthropometric parameters and gait dynamics.Medical & biological engineering & computing · 2025Article
- Varus deformity in medial knee osteoarthritis correlates with fatty degeneration of lower limb muscles: Artificial intelligence-based computed tomography analysis.Journal of experimental orthopaedics · 2025Article
- Three-Dimensional gait biomechanics in patients with mild knee osteoarthritis.Scientific reports · 2025Article
- Gait biomechanics and postural adaptations in forward head posture: a comparative cross-sectional study.BMC musculoskeletal disorders · 2025Article
- The articularis genu as a surrogate for structural determinants of peri-articular myopenia in osteoarthritis.Scientific reports · 2025Article
- Thigh muscle features in female patients with severe knee osteoarthritis: a cross-sectional study.BMC musculoskeletal disorders · 2025Article
- Factors, characteristics and influences of the changes of muscle activation patterns for patients with knee osteoarthritis: a review.Journal of orthopaedic surgery and research · 2025Review
- Prevalence and location of myofascial trigger points in dogs with osteoarthritis.Frontiers in veterinary science · 2025Article
- The effect of mild to moderate knee osteoarthritis on gait and three-dimensional biomechanical alterations.Frontiers in bioengineering and biotechnology · 2025Article
- The Effect of Thigh Muscle Forces on Knee Contact Force in Female Patients with Severe Knee Osteoarthritis.Bioengineering (Basel, Switzerland) · 2024Article
- Current Evidence on and Clinical Implications of Vitamin D Levels in Pain and Functional Management of Knee Osteoarthritis: A Systematic Review.Clinics and practice · 2024Review
- Muscle activation patterns and gait changes in unilateral knee osteoarthritis patients: a comparative study with healthy controls.Clinical rheumatology · 2024Article
- A Motion Capture Dataset on Human Sitting to Walking Transitions.Scientific data · 2024Article
- Estimation of patient-reported outcome measures based on features of knee joint muscle co-activation in advanced knee osteoarthritis.Scientific reports · 2024Article
- Integrative approach to pedobarography and pelvis-trunk motion for knee osteoarthritis detection and exploration of non-radiographic rehabilitation monitoring.Frontiers in bioengineering and biotechnology · 2024Article
- The influence of obesity and fat distribution on ankle muscle coactivation during gait.PloS one · 2024Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
The primary role of muscles is to move, and control joints. It is therefore important to understand how degenerative joint disease changes this role with the resulting effect on mechanical joint loading. Muscular control strategies can vary depending on strength and coordination which in turn influences joint control and loading. The purpose of this study was to investigate the variation in neuromuscular control mechanisms and joint biomechanics for three subject groups including those with: uni-compartmental knee osteoarthritis (OA), listed for high tibial osteotomy surgery (pre-HTO, n = 10); multi-compartmental knee OA listed for total knee replacement (pre-TKR, n = 9), and non-pathological knees (NP, n = 11). Lower limb kinematics and electromyography (EMG) data for subjects walking at self-selected speed, were input to an EMG-driven musculoskeletal knee model which was scaled and calibrated to each individual to estimate muscle forces. Compared to NP, the peak gastrocnemius muscle force reduced by 30% and 18% for pre-HTO and pre-TKR respectively, and the peak force estimated for hamstring muscle increased by 25% for pre-HTO. Higher quadriceps and hamstring forces suggest that co-contraction with the gastrocnemius could lead to higher joint contact forces. Combined with the excessive loading due to a high external knee adduction moment this may exacerbate joint destruction. An increased lateral muscle co-contraction reflects the progression from NP to uni-compartmental OA (pre-HTO). Pre-TKR patients adopt a different gait pattern to pre-HTO patients. Increased medial muscle co-activation could potentially differentiate between uni- or multi-compartmental OA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.