Evidence map›Paper›PMID 35051008›Full record

ArticleToxins2022

Regulation of

Jeroen L A Pennings, Eric Abachin, Raphaël Esson, Hennie Hodemaekers, Antoine Francotte, Jean-Baptiste Claude, Céline Vanhee, Sylvie Uhlrich, Rob J Vandebriel

Open access · goldAbstract read
In one paragraph

Article in Toxins, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Jeroen L A PenningsCentre for Health Protection, National Institute for Public Health and the Environment (RIVM), 3721 MA Bilthoven, The Netherlands.ORCID 0000-0002-9188-6358
Eric AbachinSanofi Pasteur, 1541 Avenue Marcel Mérieux, 69280 Marcy l'Etoile, France.
Raphaël EssonSanofi Pasteur, 1541 Avenue Marcel Mérieux, 69280 Marcy l'Etoile, France.ORCID 0000-0003-3973-4725
Hennie HodemaekersCentre for Health Protection, National Institute for Public Health and the Environment (RIVM), 3721 MA Bilthoven, The Netherlands.
Antoine FrancotteDepartment of Chemical and Physical Health Risks, Sciensano, 14 Rue Juliette Wytsman, 1050 Brussels, Belgium.
Jean-Baptiste ClaudeIVIDATA Life Sciences, 79-83 Rue Baudin, 92300 Levallois Perret, France.
Céline VanheeDepartment of Chemical and Physical Health Risks, Sciensano, 14 Rue Juliette Wytsman, 1050 Brussels, Belgium.
Sylvie UhlrichSanofi Pasteur, 1541 Avenue Marcel Mérieux, 69280 Marcy l'Etoile, France.
Rob J VandebrielCentre for Health Protection, National Institute for Public Health and the Environment (RIVM), 3721 MA Bilthoven, The Netherlands.ORCID 0000-0001-9140-952X
Institut Mérieux (France) · FRNational Institute for Public Health and the Environment · NLSciensano (Belgium) · BEArysta LifeScience (France) · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEnsuring consistency of tetanus neurotoxin (TeNT) production by

methodsWe applied RNA sequencing (RNA-Seq) to study

resultsWe identified 1381 time-dependent differentially expressed genes (DEGs) reflecting, among others, changes in growth rate and metabolism. Comparing non-standard versus standard culture conditions identified 82 condition-dependent DEGs, most of which were specific for one condition. The tetanus neurotoxin gene (

conclusionsNon-standard culture conditions lead to different gene expression responses. The

Indexed as

Base SequenceCells, CulturedClostridium tetaniGene Expression Regulation, BacterialNeurotoxinsTetanus ToxoidNeurotoxinsTetanus Toxoid3Rs principlesconsistency approachgene expressionnext-generation sequencingtargeted LC-MS/MStetanus vaccine

Identifiers

PMID35051008
PMCPMC8778922
OpenAlexW4206735819

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.