ArticleeLife2022
Human interictal epileptiform discharges are bidirectional traveling waves echoing ictal discharges.
Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- Robust time delay estimation for measurement of ictal EEG traveling waves.Journal of neural engineering · 2026Article
- Traveling waves along the cortical depth reflect structured synaptic inputs.Research square · 2026Article
- Laminar organization of cellular microcircuits modulating human interictal epileptiform discharges.Nature neuroscience · 2026Article
- Traveling-wave transcranial alternating current stimulation (twtACS) causally links neural timing to cognitive function.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Detrended fluctuation analysis of amygdala-hippocampal beta synchrony reveals network rigidity in depression associated with temporal lobe epilepsy.Journal of neural engineering · 2026Article
- Propofol-induced loss of responsiveness reorganizes cortical traveling waves in the human brain.bioRxiv : the preprint server for biology · 2026Article
- Mapping intraoperative interictal epileptiform discharges using high-resolution, thin-film cortical arrays.Epilepsia · 2026Article
- Hierarchical Flows of Human Cortical Activity.bioRxiv : the preprint server for biology · 2026Article
- A network-based EEG source imaging framework for noninvasive localization of epileptogenic zones in MRI-negative focal drug-resistant epilepsy.BMC neurology · 2026Article
- GLUT1-DS Brain Organoids Exhibit Increased Sensitivity to Metabolic and Pharmacological Induction of Epileptiform Activity.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Toward Unified Biomarkers for Focal Epilepsy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Artificial intelligence for automated detection of interictal epileptiform discharges: methodological progress, clinical evaluation, and neurodevelopmental context.Frontiers in cell and developmental biology · 2026Review
- Medtronic Percept™ recorded LFP pre-processing to remove noise and cardiac signals from neural recordings.Journal of neural engineering · 2025Review
- Mesial-to-lateral gradients of epileptiform activity to localize mesial temporal lobe epilepsy.Epilepsia · 2025Article
- Non-synaptic interictal epileptiform discharges propagating from CA3 to CA1 induce synaptic depression in the hippocampus.Epilepsia open · 2025Article
- Macroscale Traveling Waves Evoked by Single-Pulse Stimulation of the Human Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Interictal discharges spread along local recurrent networks between tubers and surrounding cortex.The Journal of physiology · 2025Article
- Protocol for detecting and analyzing non-oscillatory traveling waves from high-spatiotemporal-resolution human electrophysiological recordings.STAR protocols · 2025Article
- Chemogenetics with PSAMGene therapy · 2025Article
- Deep learning in intracranial EEG for seizure detection: advances, challenges, and clinical applications.Frontiers in neuroscience · 2025Review
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13 authors.
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Abstract
Interictal epileptiform discharges (IEDs), also known as interictal spikes, are large intermittent electrophysiological events observed between seizures in patients with epilepsy. Although they occur far more often than seizures, IEDs are less studied, and their relationship to seizures remains unclear. To better understand this relationship, we examined multi-day recordings of microelectrode arrays implanted in human epilepsy patients, allowing us to precisely observe the spatiotemporal propagation of IEDs, spontaneous seizures, and how they relate. These recordings showed that the majority of IEDs are traveling waves, traversing the same path as ictal discharges during seizures, and with a fixed direction relative to seizure propagation. Moreover, the majority of IEDs, like ictal discharges, were bidirectional, with one predominant and a second, less frequent antipodal direction. These results reveal a fundamental spatiotemporal similarity between IEDs and ictal discharges. These results also imply that most IEDs arise in brain tissue outside the site of seizure onset and propagate toward it, indicating that the propagation of IEDs provides useful information for localizing the seizure focus.
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