Evidence map›Paper›PMID 35050792›Full record

ArticleJournal of applied physiology (Bethesda, Md. : 1985)2022

Diaphragm muscle fibrosis involves changes in collagen organization with mechanical implications in Duchenne muscular dystrophy.

Ridhi Sahani, C Hunter Wallace, Brian K Jones, Silvia S Blemker

Open access · greenAbstract read
In one paragraph

Article in Journal of applied physiology (Bethesda, Md. : 1985), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 47 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ridhi SahaniDepartment of Biomedical Engineering, University of Virginia, Charlottesville, Virginia.ORCID 0000-0001-9795-4932
C Hunter WallaceDepartment of Biomedical Engineering, University of Virginia, Charlottesville, Virginia.ORCID 0000-0002-9061-8001
Brian K JonesDepartment of Biomedical Engineering, University of Virginia, Charlottesville, Virginia.
Silvia S BlemkerDepartment of Biomedical Engineering, University of Virginia, Charlottesville, Virginia.ORCID 0000-0002-2019-1153
University of Virginia · US

Funding

Biotechnology Training ProgramT32GM136615 · NIGMS · UNIVERSITY OF VIRGINIA · PI Silvia Salinas Blemker, Kimberly A. Kelly · 2020 to 2026
$3.4M
NIAMS NIH HHS U01AR06393NIGMS NIH HHS T32 GM136615NIGMS NIH HHS T32-GM136615-01
6 · The paper itself

Abstract

In Duchenne muscular dystrophy (DMD), diaphragm muscle dysfunction results in respiratory insufficiency, a leading cause of death in patients. Increased muscle stiffness occurs with buildup of fibrotic tissue, characterized by excessive accumulation of extracellular matrix (ECM) components such as collagen, and prevents the diaphragm from achieving the excursion lengths required for respiration. However, changes in mechanical properties are not explained by collagen amount alone and we must consider the complex structure and mechanics of fibrotic tissue. The goals of our study were to

Indexed as

CollagenDiaphragmFibrosisMuscular Dystrophy, DuchenneAnimalsDisease Models, AnimalHumansMiceMice, Inbred C57BLMice, Inbred mdxMicroscopy, Electron, ScanningCollagencollagen organizationDuchenne muscular dystrophyextracellular matrix mechanicsfibrosis

Identifiers

PMID35050792
PMCPMC9076426
OpenAlexW4220779043

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.