SynthesisCirculation2022
Circulating Metabolome and White Matter Hyperintensities in Women and Men.
Synthesis in Circulation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- A spatially resolved genomic-molecular atlas of human white-matter microstructure.medRxiv : the preprint server for health sciences · 2026Article
- The blood metabolome of brain health in midlife and influences of genes, microbiome and exposome.Nature aging · 2026Article
- White matter hyperintensities are associated with locus coeruleus atrophy and astrocytic βAlzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Resolving cognitive heterogeneity in white matter hyperintensities through integrated analyses of microbiome, metabolome, and brain glymphatic function.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Gut microbiome-immune-metabolic mechanisms in cerebrovascular disease: evidence-graded insights from cerebral small vessel disease, ischemic stroke, and intracerebral hemorrhage.Frontiers in microbiology · 2026Review
- Association Between Plasma Metabolomic Profile and Machine Learning-Based Brain Age.Aging cell · 2025Article
- Plasma Metabolites Link Non-Communicable Diseases to Increased White Matter Hyperintensities.CNS neuroscience & therapeutics · 2025Article
- Long-Term Impact of Using Mobile Phones and Playing Computer Games on the Brain Structure and the Risk of Neurodegenerative Diseases: Large Population-Based Study.Journal of medical Internet research · 2025Article
- Deep and periventricular white matter hyperintensities exhibit differential metabolic profiles in arteriosclerotic cerebral small vessel disease: an untargeted metabolomics study.Frontiers in neuroscience · 2025Article
- The blood metabolome of cognitive function and brain health in middle-aged adults - influences of genes, gut microbiome, and exposome.medRxiv : the preprint server for health sciences · 2024Article
- Machine learning based metabolomic and genetic profiles for predicting multiple brain phenotypes.Journal of translational medicine · 2024Article
- Sex Differences in Frequency, Severity, and Distribution of Cerebral Microbleeds.JAMA network open · 2024Article
- Sex-Dependent Effects of Cardiometabolic Health andNeurology · 2024Article
- Article
- Large-Scale Population-Based Studies of Blood Metabolome and Brain Health.Current topics in behavioral neurosciences · 2024Review
- Associations between adiposity and white matter hyperintensities: Cross-sectional and longitudinal analyses of 34,653 participants.Human brain mapping · 2024Article
- Blood-brain barrier leakage hotspots collocating with brain lesions due to sporadic and monogenic small vessel disease.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Association of Baseline Metabolomic Profiles With Incident Stroke and Dementia and With Imaging Markers of Cerebral Small Vessel Disease.Neurology · 2023Article
- Investigating associations between blood metabolites, later life brain imaging measures, and genetic risk for Alzheimer's disease.Alzheimer's research & therapy · 2023Article
- Pharmacometabolomics for the Study of Lipid-Lowering Therapies: Opportunities and Challenges.International journal of molecular sciences · 2023Review
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Authors and funding
40 authors at 16 institutions in 8 countries.
Funding
Abstract
backgroundWhite matter hyperintensities (WMH), identified on T2-weighted magnetic resonance images of the human brain as areas of enhanced brightness, are a major risk factor of stroke, dementia, and death. There are no large-scale studies testing associations between WMH and circulating metabolites.
methodsWe studied up to 9290 individuals (50.7% female, average age 61 years) from 15 populations of 8 community-based cohorts. WMH volume was quantified from T2-weighted or fluid-attenuated inversion recovery images or as hypointensities on T1-weighted images. Circulating metabolomic measures were assessed with mass spectrometry and nuclear magnetic resonance spectroscopy. Associations between WMH and metabolomic measures were tested by fitting linear regression models in the pooled sample and in sex-stratified and statin treatment-stratified subsamples. Our basic models were adjusted for age, sex, age×sex, and technical covariates, and our fully adjusted models were also adjusted for statin treatment, hypertension, type 2 diabetes, smoking, body mass index, and estimated glomerular filtration rate. Population-specific results were meta-analyzed using the fixed-effect inverse variance-weighted method. Associations with false discovery rate (FDR)-adjusted
resultsIn the meta-analysis of results from the basic models, we identified 30 metabolomic measures associated with WMH (
conclusionsCirculating metabolomic measures, including multiple lipid measures (eg, lysophosphatidylcholines, hydroxysphingomyelins, low-density lipoprotein size and composition) and nonlipid metabolites (eg, hydroxyphenylpyruvate, glucuronate), associate with WMH in a general population of middle-aged and older adults. Some metabolomic measures show marked sex specificities and explain a sizable proportion of WMH variance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.