Evidence map›Paper›PMID 35050489›Full record

ReviewDrugs & aging2022

Complement Mediators in Development to Treat Age-Related Macular Degeneration.

Marcella Nebbioso, Federica Franzone, Alessandro Lambiase, Samanta Taurone, Marco Artico, Magda Gharbiya, Antonio Greco, Antonella Polimeni

Abstract readReview
PubMed Publisher
In one paragraph

Review in Drugs & aging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Oxidative Stress Implication in Retinal Diseases-A Review.Antioxidants (Basel, Switzerland) · 2022
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Marcella Nebbioso *Department of Sense Organs, Sapienza University of Rome, piazz.le A. Moro 5, 00185, Rome, Italy. marcella.nebbioso@uniroma1.it.ORCID 0000-0002-5512-0849
Federica Franzone *Department of Sense Organs, Sapienza University of Rome, piazz.le A. Moro 5, 00185, Rome, Italy. federica.franzone91@gmail.com.
Alessandro LambiaseDepartment of Sense Organs, Sapienza University of Rome, piazz.le A. Moro 5, 00185, Rome, Italy.
Samanta TauroneIRCCS, Fondazione Bietti, Via Livenza 3, 00198, Rome, Italy.
Marco ArticoDepartment of Sense Organs, Sapienza University of Rome, piazz.le A. Moro 5, 00185, Rome, Italy.
Magda GharbiyaDepartment of Sense Organs, Sapienza University of Rome, piazz.le A. Moro 5, 00185, Rome, Italy.
Antonio GrecoDepartment of Sense Organs, Sapienza University of Rome, piazz.le A. Moro 5, 00185, Rome, Italy.
Antonella PolimeniDepartment of Oral and Maxillofacial Sciences, Sapienza University of Rome 5, 00185, Rome, Italy.
Sapienza University of Rome · ITPoliclinico Umberto I · ITFondazione G.B. Bietti · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Over recent years, great attention has been paid to the role of the complement system in the pathogenesis of age-related macular degeneration (AMD). In particular, several studies have highlighted a link between AMD development and complement dysregulation, which can probably be explained as a complement cascade hyperactivation resulting from the presence of a series of risk factors such as aging; smoking; obesity; alcohol consumption; exposure to pesticides, industrial chemicals, or pollution; and other causes of oxidative stress. This hypothesis has been mainly supported by the presence of complement mediators as constituents of drusen, representing one of the earliest and most characteristic signs of retinal damage in AMD. Additionally, activated complement mediators and some complement regulators, such as vitronectin, have been found not only in the drusen and adjacent retinal areas but also in the peripheral blood of patients with AMD. Therefore, we aim to provide a review of recently studied complement factors to highlight their role in the pathogenesis of AMD and to evaluate new potential therapeutic strategies.

Indexed as

Macular DegenerationAgingComplement ActivationComplement System ProteinsHumansOxidative StressComplement System Proteins

Identifiers

PMID35050489
OpenAlexW4206320507

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.