ArticleGeneral thoracic and cardiovascular surgery2022
High-grade tumor classified by new system is a prognostic predictor in resected lung adenocarcinoma.
Article in General thoracic and cardiovascular surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
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Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.
- Prognostic impact of the newly revised IASLC proposed grading system for invasive lung adenocarcinoma: a systematic review and meta-analysis.World journal of surgical oncology · 2024Pooled it
- The presence of a cribriform pattern is related to poor prognosis in lung adenocarcinoma after surgical resection: A meta-analysis.General thoracic and cardiovascular surgery · 2024Pooled it
- [Predicting Invasive Non-mucinous Lung Adenocarcinoma IASLC Grading: A Nomogram Based on Dual-energy CT Imaging and Conventional Features].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2025Article
- Does grade matter? Evaluation of histologic grade in patients with stage 1 non-small cell lung cancer using the National Cancer Database.JTCVS open · 2025Article
- Predictive value of perioperative carcinoembryonic antigen changes for recurrence in non-small cell lung cancer.Translational lung cancer research · 2025Article
- Predicting malignant risk of ground-glass nodules using convolutional neural networks based on dual-time-pointCancer imaging : the official publication of the International Cancer Imaging Society · 2025Article
- Combination of grade and spread through air spaces (STAS) predicts recurrence in early stage lung adenocarcinoma: a retrospective cohort study.Updates in surgery · 2025Article
- Predicting pathological grade of stage I pulmonary adenocarcinoma: a CT radiomics approach.Frontiers in oncology · 2024Article
- A pretreatment prediction model of grade 3 tumors classed by the IASLC grading system in lung adenocarcinoma.BMC pulmonary medicine · 2023Article
- PB-LNet: a model for predicting pathological subtypes of pulmonary nodules on CT images.BMC cancer · 2023Article
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Authors and funding
6 authors at 2 institutions in 1 country.
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Abstract
objectivesA grading system for pulmonary adenocarcinoma has not been established; hence, the International Association for the Study of Lung Cancer (IASLC) pathology panel developed a new grading system for invasive adenocarcinoma. We aimed to evaluate the prognostic significance of the IASLC grading system for invasive pulmonary adenocarcinoma.
methodsWe conducted a retrospective analysis of 471 Japanese patients with resected lung adenocarcinoma. Tumors were classified in accordance with the IASLC grading system and 2015 World Health Organization classification. We analyzed recurrence-free probability (RFP) and overall survival (OS) using the log-rank test and compared the two grading systems using the Cox proportional hazards model.
resultsGrade 3 tumors of the IASLC system and high-grade tumors of the 2015 World Health Organization classification were present in 38% and 17% of patients, respectively. The 5-year RFP was lower in patients with IASLC Grade 3 tumors (45%) than in patients with IASLC Grade 1 and 2 tumors (91% and 83%, respectively). The 5-year RFP of patients with IASLC Grade 2 tumors (83%) was higher than of those with 2015 World Health Organization intermediate tumors (69%). On multivariate analysis for recurrence, IASLC Grade 3 was an independent prognostic factor of worse RFP. We showed similar results on analysis for the OS.
conclusionsThe prognostic significance of IASLC Grade 3 tumors on recurrence-free probability was confirmed through both univariate and multivariate analyses. Thus, the IASLC Grade 3 tumor is an independent factor of poor prognosis in patients with resected lung adenocarcinoma.
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