Evidence map›Paper›PMID 35050154›Full record

ArticleMetabolites2022

Plasma Metabolomic Profiles Associated with Three-Year Progression of Age-Related Macular Degeneration.

Ines Lains, Kevin Mendez, Archana Nigalye, Raviv Katz, Vivian Paraskevi Douglas, Rachel S Kelly, Ivana K Kim, John B Miller, Demetrios G Vavvas, Liming Liang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolites, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ines LainsMassachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA.ORCID 0000-0002-8136-4724
Kevin MendezDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02114, USA.
Archana NigalyeMassachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA.
Raviv KatzMassachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA.
Vivian Paraskevi DouglasMassachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA.
Rachel S KellyDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02114, USA.ORCID 0000-0003-3023-1822
Ivana K KimMassachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA.
John B MillerMassachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA.ORCID 0000-0003-0109-9738
Demetrios G VavvasMassachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA.
Liming LiangSystems Genetics and Genomics Unit, Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02114, USA.
Jessica Lasky-SuDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02114, USA.
Joan W MillerMassachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA.
Deeba HusainMassachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA.

Funding

Metabolomics a Novel Tool for Investigating the Pathogenesis of Age-related Macular DegenerationR01EY030088 · NEI · MASSACHUSETTS EYE AND EAR INFIRMARY · PI Deeba Husain · 2020 to 2026
$3.5M
Multi-Omic Endotyping of AsthmaK01HL146980 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI KELLY, RACHEL SABINE · 2019 to 2023
$891k
Champalimaud Foundation awardGovernment of Portugal HMSP-ICJ/006/2013Massachusetts Lions Eye Research Fund HusainNational Institute of Health RO1EY030088NEI NIH HHS R01 EY030088NHLBI NIH HHS K01 HL146980Research to Prevent Blindness department grant
6 · The paper itself

Abstract

Plasma metabolomic profiles have been shown to be associated with age-related macular degeneration (AMD) and its severity stages. However, all studies performed to date have been cross-sectional and have not assessed progression of AMD. This prospective, longitudinal, pilot study analyzes, for the first time, the association between plasma metabolomic profiles and progression of AMD over a 3-year period. At baseline and 3 years later, subjects with AMD (

Indexed as

age-related macular degenerationdark adaptationmetabolomicsplasma

Identifiers

PMID35050154
PMCPMC8780121

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.