ArticleJournal of fungi (Basel, Switzerland)2022
Investigations upon the Improvement of Dermatophyte Identification Using an Online Mass Spectrometry Application.
Article in Journal of fungi (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Current Performance of MALDI-TOF Mass Spectrometry Databases for the Identification of Dermatophyte Species.Journal of fungi (Basel, Switzerland) · 2025Article
- Identification of Challenging Dermatophyte Species Using Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry.Journal of fungi (Basel, Switzerland) · 2025Article
- Monocentric evaluation of the Novaplex dermatophyte multiplex qPCR assay in the diagnosis of dermatophytoses.Journal of clinical microbiology · 2024Article
- Improving the Detection of Epidemic Clones inMicroorganisms · 2023Article
- MALDI-TOF Mass Spectrometry Online Identification ofJournal of fungi (Basel, Switzerland) · 2022Article
- Phytochemical Screening, Antifungal, and Anticancer Activities of Medicinal PlantsBioMed research international · 2022Article
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Authors and funding
11 authors.
Funding
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Abstract
Online MALDI-TOF mass spectrometry applications, such as MSI-2, have been shown to help identify dermatophytes, but recurrent errors are still observed between phylogenetically close species. The objective of this study was to assess different approaches to reduce the occurrence of such errors by adding new reference spectra to the MSI-2 application. Nine libraries were set up, comprising an increasing number of spectra obtained from reference strains that were submitted to various culture durations on two distinct culture media: Sabouraud gentamicin chloramphenicol medium and IDFP Conidia medium. The final library included spectra from 111 strains of 20 species obtained from cultures on both media collected every three days after the appearance of the colony. The performance of each library was then analyzed using a cross-validation approach. The spectra acquisitions were carried out using a Microflex Bruker spectrometer. Diversifying the references and adding spectra from various culture media and culture durations improved identification performance. The percentage of correct identification at the species level rose from 63.4 to 91.7% when combining all approaches. Nevertheless, residual confusion between close species, such as
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