Evidence map›Paper›PMID 35049941›Full record

ArticleJournal of fungi (Basel, Switzerland)2021

Overcome Double Trouble: Baloxavir Marboxil Suppresses Influenza Thereby Mitigating Secondary Invasive Pulmonary Aspergillosis.

Laura Seldeslachts, Cato Jacobs, Birger Tielemans, Eliane Vanhoffelen, Lauren Van der Sloten, Stephanie Humblet-Baron, Lieve Naesens, Katrien Lagrou, Erik Verbeken, Joost Wauters and 1 more

Open access · goldAbstract read
In one paragraph

Article in Journal of fungi (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Viral reactivations and fungal infections in nonresolving acute respiratory distress syndrome.European respiratory review : an official journal of the European Respiratory Society · 2025
    Review
  3. IMA fungus · 2025
    Article
  4. Article
  5. ProcCluster® and procaine hydrochloride inhibit the growth ofFrontiers in cellular and infection microbiology · 2024
    Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Laura SeldeslachtsBiomedical MRI Unit/MoSAIC, Department of Imaging and Pathology, KU Leuven, 3000 Leuven, Belgium.ORCID 0000-0002-9562-2923
Cato JacobsLaboratory for Clinical Infectious and Inflammatory Disorders, Department of Microbiology, Immunology and Transplantation, KU Leuven, 3000 Leuven, Belgium.
Birger TielemansBiomedical MRI Unit/MoSAIC, Department of Imaging and Pathology, KU Leuven, 3000 Leuven, Belgium.ORCID 0000-0002-1775-1797
Eliane VanhoffelenBiomedical MRI Unit/MoSAIC, Department of Imaging and Pathology, KU Leuven, 3000 Leuven, Belgium.
Lauren Van der SlotenLaboratory for Clinical Infectious and Inflammatory Disorders, Department of Microbiology, Immunology and Transplantation, KU Leuven, 3000 Leuven, Belgium.
Stephanie Humblet-BaronLaboratory of Adaptive Immunity, Department of Microbiology, Immunology and Transplantation, KU Leuven, 3000 Leuven, Belgium.
Lieve NaesensLaboratory of Virology and Chemotherapy, Rega Institute, Department of Microbiology, Immunology and Transplantation, KU Leuven, 3000 Leuven, Belgium.ORCID 0000-0001-9742-9302
Katrien LagrouLaboratory of Clinical Bacteriology and Mycology, Department of Microbiology, Immunology and Transplantation, KU Leuven, 3000 Leuven, Belgium.ORCID 0000-0001-8668-1350
Erik VerbekenDepartment of Imaging and Pathology, KU Leuven, 3000 Leuven, Belgium.
Joost WautersLaboratory for Clinical Infectious and Inflammatory Disorders, Department of Microbiology, Immunology and Transplantation, KU Leuven, 3000 Leuven, Belgium.
Greetje Vande VeldeBiomedical MRI Unit/MoSAIC, Department of Imaging and Pathology, KU Leuven, 3000 Leuven, Belgium.ORCID 0000-0002-5633-3993
KU Leuven · BERega Institute for Medical Research · BE

Funding

KU Leuven C24/17/061Research Foundation - Flanders 1186121NResearch Foundation - Flanders 1506114NResearch Foundation - Flanders G053121NResearch Foundation - Flanders G057721N
6 · The paper itself

Abstract

Influenza-associated pulmonary aspergillosis (IAPA) is a global recognized superinfection in critically ill influenza patients. Baloxavir marboxil, a cap-dependent endonuclease inhibitor, is a newly approved anti-influenza therapeutic. Although the benefits as a treatment for influenza are clear, its efficacy against an influenza-

Indexed as

Aspergillus fumigatusbaloxavir marboxilinfluenzainfluenza-associated pulmonary aspergillosis (IAPA)multimodal preclinical imaging-supported mouse model

Identifiers

PMID35049941
PMCPMC8777735
OpenAlexW4200413698

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.