ReviewMarine drugs2022
Extremophilic Fungi from Marine Environments: Underexplored Sources of Antitumor, Anti-Infective and Other Biologically Active Agents.
Review in Marine drugs, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The trial behind it
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Who cites it
20 citing papers in PubMed, 41 citations in OpenAlex.
- Identification of new ER-targeted anticancer hits active against MCF-7 breast cancer cells in the marine fungal secondary metabolite library using computative and experimental approaches.Journal of computer-aided molecular design · 2026Article
- Statistical investigation of marine bacterial extracellular polysaccharides: deciphering the interplay among environmental adaptation, species distribution, and biomedical potential.Marine life science & technology · 2026Review
- Deciphering the Function and Structure of PA1216 as an S-Adenosyl-l-Methionine Binding Protein Using Differential Scanning Fluorimetry and Circular Dichroism.Protein science : a publication of the Protein Society · 2026Article
- Marine Yeasts for Biotechnology: Potential Applications and Insights from Comparisons with Terrestrial Yeasts.Journal of fungi (Basel, Switzerland) · 2026Review
- Potential of Indonesian Marine Endophytic Fungi as Extracellular Enzymes Producers.Journal of fungi (Basel, Switzerland) · 2026Article
- Fungi as a source of anticancer agents: metabolic products and their functional implications.Archives of microbiology · 2026Review
- Metabolic response ofFrontiers in microbiology · 2026Article
- Genetic and biotechnological potential of thermophilic Streptomyces sp. isolated from Baikal freshwater psychrophilic sponge.Scientific reports · 2025Article
- Anti-neuroinflammatory polyketides from the medicinal herb-derived fungal strain Didymocyrtis brachylaenae Km1530.Journal of food and drug analysis · 2025Article
- Mannan-Containing Polymers from Hadal BacteriumMarine drugs · 2025Article
- Salt-Adapted Microorganisms: A Promising Resource for Novel Anti-Cancer Drug Discovery.Marine drugs · 2025Review
- Halophilic Fungi-Features and Potential Applications.Microorganisms · 2025Review
- Advances in the Study of Halogenated Natural Products.Current topics in medicinal chemistry · 2025Review
- The Cytotoxic Properties of Extreme Fungi's Bioactive Components-An Updated Metabolic and Omics Overview.Life (Basel, Switzerland) · 2023Review
- Modern Trends in Natural Antibiotic Discovery.Life (Basel, Switzerland) · 2023Review
- Study of marine microorganism metabolites: new resources for bioactive natural products.Frontiers in microbiology · 2023Review
- Novel Sesquiterpene and Diterpene Aminoglycosides from the Deep-Sea-Sediment FungusMarine drugs · 2022Article
- Fungal Bergamotane Sesquiterpenoids-Potential Metabolites: Sources, Bioactivities, and Biosynthesis.Marine drugs · 2022Review
- Basal Parasitic Fungi in Marine Food Webs-A Mystery Yet to Unravel.Journal of fungi (Basel, Switzerland) · 2022Review
- Exploring the anticancer activities of novel bioactive compounds derived from endophytic fungi: mechanisms of action, current challenges and future perspectives.American journal of cancer research · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Marine environments are underexplored terrains containing fungi that produce a diversity of natural products given unique environmental pressures and nutrients. While bacteria are commonly the most studied microorganism for natural products in the marine world, marine fungi are also abundant but remain an untapped source of bioactive metabolites. Given that their terrestrial counterparts have been a source of many blockbuster antitumor agents and anti-infectives, including camptothecin, the penicillins, and cyclosporin A, marine fungi also have the potential to produce new chemical scaffolds as leads to potential drugs. Fungi are more phylogenetically diverse than bacteria and have larger genomes that contain many silent biosynthetic gene clusters involved in making bioactive compounds. However, less than 5% of all known fungi have been cultivated under standard laboratory conditions. While the number of reported natural products from marine fungi is steadily increasing, their number is still significantly lower compared to those reported from their bacterial counterparts. Herein, we discuss many varied cytotoxic and anti-infective fungal metabolites isolated from extreme marine environments, including symbiotic associations as well as extreme pressures, temperatures, salinity, and light. We also discuss cultivation strategies that can be used to produce new bioactive metabolites or increase their production. This review presents a large number of reported structures though, at times, only a few of a large number of related structures are shown.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.