Evidence map›Paper›PMID 35049811›Full record

ArticleAnimals : an open access journal from MDPI2022

Platelet Lysate for Mesenchymal Stromal Cell Culture in the Canine and Equine Species: Analogous but Not the Same.

Alina Hagen, Heidrun Holland, Vivian-Pascal Brandt, Carla U Doll, Thomas C Häußler, Michaela Melzer, Julia Moellerberndt, Hendrik Lehmann, Janina Burk

Open access · goldAbstract read
In one paragraph

Article in Animals : an open access journal from MDPI, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
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  7. Stem Cells in Domestic Animals: Applications in Health and Production.Animals : an open access journal from MDPI · 2022
    Article
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  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Alina HagenEquine Clinic (Surgery, Orthopedics), Justus-Liebig-University Giessen, 35390 Giessen, Germany.
Heidrun HollandSaxon Incubator for Clinical Translation (SIKT), University of Leipzig, 04109 Leipzig, Germany.
Vivian-Pascal BrandtSaxon Incubator for Clinical Translation (SIKT), University of Leipzig, 04109 Leipzig, Germany.
Carla U DollEquine Clinic (Surgery, Orthopedics), Justus-Liebig-University Giessen, 35390 Giessen, Germany.
Thomas C HäußlerSmall Animal Clinic (Surgery), Justus-Liebig-University Giessen, 35390 Giessen, Germany.ORCID 0000-0001-7070-8141
Michaela MelzerEquine Clinic (Surgery, Orthopedics), Justus-Liebig-University Giessen, 35390 Giessen, Germany.
Julia MoellerberndtEquine Clinic (Surgery, Orthopedics), Justus-Liebig-University Giessen, 35390 Giessen, Germany.
Hendrik LehmannDepartment of Veterinary Clinical Sciences, Small Animal Clinic, Justus-Liebig-University Giessen, 35390 Giessen, Germany.
Janina BurkEquine Clinic (Surgery, Orthopedics), Justus-Liebig-University Giessen, 35390 Giessen, Germany.ORCID 0000-0002-7868-0355
Justus-Liebig-Universität Gießen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Platelet lysate (PL) is an attractive platelet-based therapeutic tool and has shown promise as xeno-free replacement for fetal bovine serum (FBS) in human and equine mesenchymal stromal cell (MSC) culture. Here, we established a scalable buffy-coat-based protocol for canine PL (cPL) production (n = 12). The cPL was tested in canine adipose MSC (n = 5) culture compared to FBS. For further comparison, equine adipose MSC (n = 5) were cultured with analogous equine PL (ePL) or FBS. During canine blood processing, platelet and transforming growth factor-β1 concentrations increased (

Indexed as

caninecell fitnessequinemesenchymal stromal cells (MSC)platelet lysate

Identifiers

PMID35049811
PMCPMC8773277
OpenAlexW4206060741

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.