Evidence map›Paper›PMID 35049733›Full record

ArticleBioengineering (Basel, Switzerland)2022

Unraveling the Mechanism of Platelet Aggregation Suppression by Monoterpenoids.

Liliya E Nikitina, Roman S Pavelyev, Ilmir R Gilfanov, Sergei V Kiselev, Zulfiya R Azizova, Alexander A Ksenofontov, Pavel S Bocharov, Elena V Antina, Vladimir V Klochkov, Ayzira F Timerova and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioengineering (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 6 institutions in 1 country.

Liliya E NikitinaGeneral and Organic Chemistry Department, Kazan State Medical University, 49 Butlerova st., 420012 Kazan, Russia.ORCID 0000-0003-2113-5732
Roman S PavelyevMedical Physics Department, Kazan Federal University, 18 Kremlyovskaya st., 420008 Kazan, Russia.ORCID 0000-0002-3195-1218
Ilmir R GilfanovGeneral and Organic Chemistry Department, Kazan State Medical University, 49 Butlerova st., 420012 Kazan, Russia.
Sergei V KiselevGeneral and Organic Chemistry Department, Kazan State Medical University, 49 Butlerova st., 420012 Kazan, Russia.
Zulfiya R AzizovaGeneral and Organic Chemistry Department, Kazan State Medical University, 49 Butlerova st., 420012 Kazan, Russia.
Alexander A KsenofontovG.A. Krestov Institute of Solution Chemistry of Russian Academy of Sciences, 1 Akademicheskaya st., 153045 Ivanovo, Russia.ORCID 0000-0001-8681-0335
Pavel S BocharovG.A. Krestov Institute of Solution Chemistry of Russian Academy of Sciences, 1 Akademicheskaya st., 153045 Ivanovo, Russia.
Elena V AntinaG.A. Krestov Institute of Solution Chemistry of Russian Academy of Sciences, 1 Akademicheskaya st., 153045 Ivanovo, Russia.
Vladimir V KlochkovMedical Physics Department, Kazan Federal University, 18 Kremlyovskaya st., 420008 Kazan, Russia.
Ayzira F TimerovaMedical Physics Department, Kazan Federal University, 18 Kremlyovskaya st., 420008 Kazan, Russia.
Ilfat Z RakhmatullinMedical Physics Department, Kazan Federal University, 18 Kremlyovskaya st., 420008 Kazan, Russia.
Olga V OstolopovskayaGeneral and Organic Chemistry Department, Kazan State Medical University, 49 Butlerova st., 420012 Kazan, Russia.
Mohammed A KhelkhalMedical Physics Department, Kazan Federal University, 18 Kremlyovskaya st., 420008 Kazan, Russia.
Sergei V BoichukGeneral and Organic Chemistry Department, Kazan State Medical University, 49 Butlerova st., 420012 Kazan, Russia.ORCID 0000-0003-2415-1084
Aigul R GalembikovaGeneral and Organic Chemistry Department, Kazan State Medical University, 49 Butlerova st., 420012 Kazan, Russia.ORCID 0000-0002-0293-2974
Natalia S AndriutsaInstitute of the Biological Design and Modelling of Complex Systems, I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation, md. Edalgo 7, apt. 219, 108801 Moscow, Russia.ORCID 0000-0001-5425-7707
Larisa L FrolovaInstitute of Chemistry, Federal Research Center, Komi Scientific Center, Ural Branch of the Russian Academy of Sciences, Pervomayskaya st. 48, 167982 Syktyvkar, Russia.
Alexander V KutchinInstitute of Chemistry, Federal Research Center, Komi Scientific Center, Ural Branch of the Russian Academy of Sciences, Pervomayskaya st. 48, 167982 Syktyvkar, Russia.
Airat R KayumovMedical Physics Department, Kazan Federal University, 18 Kremlyovskaya st., 420008 Kazan, Russia.ORCID 0000-0001-7195-1557
Kazan State Medical University · RUKazan Federal University · RUInstitute of Solution Chemistry · RUUral Branch of the Russian Academy of Sciences · RUIvanovo State University of Chemistry and Technology · RUSechenov University · RU

Funding

Council on grants of the President of the Russian Federation МК-197.2021.1.3Kazan Federal University Strategic Academic Leadership Program no numberRussian Science Foundation 20-64-47014
6 · The paper itself

Abstract

Platelet aggregation causes various diseases and therefore challenges the development of novel antiaggregatory drugs. In this study, we report the possible mechanism of platelet aggregation suppression by newly synthesized myrtenol-derived monoterpenoids carrying different heteroatoms (sulphur, oxygen, or nitrogen). Despite all tested compounds suppressed the platelet aggregation in vitro, the most significant effect was observed for the S-containing compounds. The molecular docking confirmed the putative interaction of all tested compounds with the platelet's P2Y

Indexed as

1D,2D solution-state NMRcell membranes modelmolecular dockingNO-containing monoterpenoidsP2Y12 receptorplatelet aggregation suppressing activityS

Identifiers

PMID35049733
PMCPMC8773274
OpenAlexW4205305612

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.