Evidence map›Paper›PMID 35049704›Full record

SynthesisCurrent oncology (Toronto, Ont.)2022

A Portrait of SARS-CoV-2 Infection in Patients Undergoing Hematopoietic Cell Transplantation: A Systematic Review of the Literature.

Adrian J M Bailey, Aidan M Kirkham, Madeline Monaghan, Risa Shorr, C Arianne Buchan, Christopher Bredeson, David S Allan

Open access · goldAbstract readSystematic Review
In one paragraph

Synthesis in Current oncology (Toronto, Ont.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Guideline
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Adrian J M BaileyFaculty of Medicine, University of Ottawa, Ottawa, ON K1H 8L6, Canada.
Aidan M KirkhamFaculty of Medicine, University of Ottawa, Ottawa, ON K1H 8L6, Canada.
Madeline MonaghanClinical Epidemiology, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.
Risa ShorrMedical Library and Learning Services, The Ottawa Hospital, Ottawa, ON K1H 8L6, Canada.
C Arianne BuchanFaculty of Medicine, University of Ottawa, Ottawa, ON K1H 8L6, Canada.
Christopher BredesonFaculty of Medicine, University of Ottawa, Ottawa, ON K1H 8L6, Canada.
David S AllanFaculty of Medicine, University of Ottawa, Ottawa, ON K1H 8L6, Canada.
Ottawa Hospital · CAUniversity of Ottawa · CAOttawa Hospital Research Institute

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The management of COVID-19 in hematopoietic cell transplant (HCT) recipients represents a special challenge given the variable states of immune dysregulation and altered vaccine efficacy in this population. A systematic search (Ovid Medline and Embase on 1 June 2021) was needed to better understand the presenting features, prognostic factors, and treatment options. Of 897 records, 29 studies were identified in our search. Most studies reporting on adults and pediatric recipients described signs and symptoms that were typical of COVID-19. Overall, the mortality rates were high, with 21% of adults and 6% of pediatric HCT recipients succumbing to COVID-19. The factors reported to be associated with increased mortality included age (HR = 1.21, 95% CI 1.03-1.43,

Indexed as

COVID-19Hematopoietic Stem Cell TransplantationChildHumansSARS-CoV-2Vaccine EfficacyCOVID-19hematopoietic cell transplantmeta-analysismortalitysystematic reviewtreatment

Identifiers

PMID35049704
PMCPMC8774852
OpenAlexW4205910034

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.