Evidence map›Paper›PMID 35049658›Full record

ReviewBiosensors2022

Advances in the Development of Phage-Based Probes for Detection of Bio-Species.

Kameshpandian Paramasivam, Yuanzhao Shen, Jiasheng Yuan, Ibtesam Waheed, Chuanbin Mao, Xin Zhou

Open access · goldAbstract readReview
In one paragraph

Review in Biosensors, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
5.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 37 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Kameshpandian ParamasivamInstitute of Comparative Medicine, College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.ORCID 0000-0002-1554-1593
Yuanzhao ShenInstitute of Comparative Medicine, College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.ORCID 0000-0001-8428-3340
Jiasheng YuanInstitute of Comparative Medicine, College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.
Ibtesam WaheedInstitute of Comparative Medicine, College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.
Chuanbin MaoStephenson Life Sciences Research Center, Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019-5300, USA.ORCID 0000-0002-8142-3659
Xin ZhouInstitute of Comparative Medicine, College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.ORCID 0000-0003-2515-704X
Yangzhou University · CNUniversity of Oklahoma · US

Funding

National Natural Science Foundation of China 31870989Yangzhou University 137011016
6 · The paper itself

Abstract

Bacteriophages, abbreviated as "phages", have been developed as emerging nanoprobes for the detection of a wide variety of biological species, such as biomarker molecules and pathogens. Nanosized phages can display a certain length of exogenous peptides of arbitrary sequence or single-chain variable fragments (scFv) of antibodies that specifically bind to the targets of interest, such as animal cells, bacteria, viruses, and protein molecules. Metal nanoparticles generally have unique plasmon resonance effects. Metal nanoparticles such as gold, silver, and magnetism are widely used in the field of visual detection. A phage can be assembled with metal nanoparticles to form an organic-inorganic hybrid probe due to its nanometer-scale size and excellent modifiability. Due to the unique plasmon resonance effect of this composite probe, this technology can be used to visually detect objects of interest under a dark-field microscope. In summary, this review summarizes the recent advances in the development of phage-based probes for ultra-sensitive detection of various bio-species, outlining the advantages and limitations of detection technology of phage-based assays, and highlighting the commonly used editing technologies of phage genomes such as homologous recombination and clustered regularly interspaced palindromic repeats/CRISPR-associated proteins system (CRISPR-Cas). Finally, we discuss the possible scenarios for clinical application of phage-probe-based detection methods.

Indexed as

BacteriophagesCRISPR-Associated ProteinsCRISPR-Cas SystemsCRISPR-Associated Proteinsbacteriophage (phage)biological detectionbiosensornanomaterialsphage-based probe

Identifiers

PMID35049658
PMCPMC8773867
OpenAlexW4205878739

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.