Evidence map›Paper›PMID 35049563›Full record

ArticleGels (Basel, Switzerland)2022

Effect on Rheological Properties and 3D Printability of Biphasic Calcium Phosphate Microporous Particles in Hydrocolloid-Based Hydrogels.

Helena Herrada-Manchón, David Rodríguez-González, Manuel Alejandro Fernández, Nathan William Kucko, Florence Barrère-de Groot, Enrique Aguilar

Open access · goldAbstract read
In one paragraph

Article in Gels (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Helena Herrada-ManchónCentro de Innovación en Química Avanzada (ORFEO-CINQA), Departamento de Química Orgánica e Inorgánica, Instituto Universitario de Química Organometálica "Enrique Moles", Universidad de Oviedo, C/Julián Clavería 8, 33006 Oviedo, Spain.
David Rodríguez-GonzálezCentro de Innovación en Química Avanzada (ORFEO-CINQA), Departamento de Química Orgánica e Inorgánica, Instituto Universitario de Química Organometálica "Enrique Moles", Universidad de Oviedo, C/Julián Clavería 8, 33006 Oviedo, Spain.ORCID 0000-0002-9078-7673
Manuel Alejandro FernándezFundación Idonial, Parque Científico y Tecnológico de Gijón, Avda, Jardín Botánico 1345, 33203 Gijón, Spain.
Nathan William KuckoKuros Biosciences BV, Professor Bronkhorstlaan 10, Building 48, 3723 MB Bilthoven, The Netherlands.ORCID 0000-0002-4904-8238
Florence Barrère-de GrootKuros Biosciences BV, Professor Bronkhorstlaan 10, Building 48, 3723 MB Bilthoven, The Netherlands.
Enrique AguilarCentro de Innovación en Química Avanzada (ORFEO-CINQA), Departamento de Química Orgánica e Inorgánica, Instituto Universitario de Química Organometálica "Enrique Moles", Universidad de Oviedo, C/Julián Clavería 8, 33006 Oviedo, Spain.ORCID 0000-0002-1186-0079
Universidad de Oviedo · ESBronkhorst (Netherlands) · NLFundación Prodintec · ES

Funding

European Union 874790
6 · The paper itself

Abstract

The production of patient-specific bone substitutes with an exact fit through 3D printing is emerging as an alternative to autologous bone grafting. To the success of tissue regeneration, the material characteristics such as porosity, stiffness, and surface topography have a strong influence on the cell-material interaction and require significant attention. Printing a soft hydrocolloid-based hydrogel reinforced with irregularly-shaped microporous biphasic calcium phosphate (BCP) particles (150-500 µm) is an alternative strategy for the acquisition of a complex network with good mechanical properties that could fulfill the needs of cell proliferation and regeneration. Three well-known hydrocolloids (sodium alginate, xanthan gum, and gelatin) have been combined with BCP particles to generate stable, homogenous, and printable solid dispersions. Through rheological assessment, it was determined that the crosslinking time, printing process parameters (infill density percentage and infill pattern), as well as BCP particle size and concentration all influence the stiffness of the printed matrices. Additionally, the swelling behavior on fresh and dehydrated 3D-printed structures was investigated, where it was observed that the BCP particle characteristics influenced the constructs' water absorption, particle diffusion out of the matrix and degradability.

Indexed as

3D printingbiphasic calcium phosphatehydrogelsrheologysolid dispersions

Identifiers

PMID35049563
PMCPMC8774978
OpenAlexW4205676313

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.