ArticleEuropean journal of endocrinology2022
Sex hormones, adiposity, and metabolic traits in men and women: a Mendelian randomisation study.
Article in European journal of endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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Who cites it
24 citing papers in PubMed, 36 citations in OpenAlex.
- Sex and age influence the association between insulin resistance and all-cause mortality in rheumatoid arthritis patients.Clinical rheumatology · 2026Article
- Associations between cardiometabolic index and sleep disorders: Results from NHANES 2015 to 2020.Medicine · 2026Article
- Association of serum testosterone concentrations with central adiposity in men who inject heroin in Mombasa County, Kenya.The Pan African medical journal · 2026Article
- Central adiposity and sex are associated with the integrative architecture of physiological networks in healthy youth: a cross-sectional study in a cohort of Chinese college students.Frontiers in physiology · 2026Article
- Association Between Obesity Indices and Heart Rate Variability: A Cross-Sectional Study in Asian Young College Students.Cardiology research and practice · 2026Article
- Associations between sex hormones and obesity-related indicators: results from the NHANES and Mendelian randomization study.European journal of medical research · 2025Article
- Predictors of Post-Bariatric Surgery Hypoglycemia: A Multicenter Retrospective Cohort Study.Endocrinology, diabetes & metabolism · 2025Article
- Global burden and trends of multiple myeloma attributable to high body mass index: a comprehensive analysis of the global burden of disease 2021 study with projections to 2040.BMC public health · 2025Article
- Effects of weight loss on testosterone, sex hormone-binding globulin, adiposity, and insulin sensitivity in women and men.Obesity (Silver Spring, Md.) · 2025Article
- Association between endogenous sex hormones and adiposity in youth across a weight status spectrum.Pediatric research · 2025Article
- Relationship of obesity, body fat, benign adrenal tumors and the mediating mechanism: a two-step mendelian randomization study.BMC cancer · 2025Article
- Metabolic impact of endogenously produced estrogens by adipose tissue in females and males across the lifespan.Frontiers in endocrinology · 2025Review
- Relationship between neck circumference and body composition: a cross-sectional study based on a Chinese population.Frontiers in public health · 2025Article
- The mediatory role of androgens on sex differences in glucose homeostasis and incidence of type 2 diabetes: the KORA study.Cardiovascular diabetology · 2024Observational
- Sex- and Gender-Related Differences in Obesity: From Pathophysiological Mechanisms to Clinical Implications.International journal of molecular sciences · 2024Review
- Possible Mechanisms Linking Obesity, Steroidogenesis, and Skeletal Muscle Dysfunction.Life (Basel, Switzerland) · 2023Review
- Immunomodulatory effects of exercise in cancer prevention and adjuvant therapy: a narrative review.Frontiers in physiology · 2023Review
- Association of sex hormones and sex hormone-binding globulin with liver fat in men and women: an observational and Mendelian randomization study.Frontiers in endocrinology · 2023Observational
- Beyond apples and pears: sex-specific genetics of body fat percentage.Frontiers in endocrinology · 2023Article
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Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
objectiveEpidemiological and clinical studies have highlighted important roles for sex hormones in the regulation of fat distribution and systemic metabolism. We investigated the bidirectional associations between bioavailable serum testosterone (BioT) in both sexes and oestradiol (E2) in men and adiposity and metabolic traits using Mendelian randomisation (MR). DESIGN AND
methodsAs genetic instruments for sex hormones, we selected all the genome-wide significant, independent signals from a genome-wide association studies (GWAS) in up to 425 097 European ancestry UK Biobank participants. European population-specific, summary-level data for adiposity, metabolic, and blood pressure traits were obtained from the largest publicly available GWAS. Sex-specific, two-sample MR analyses were used to estimate the associations of sex hormones with these traits and vice versa.
resultsIn women, higher BioT was associated with obesity, upper-body fat distribution, and low HDL-cholesterol although, based on analyses modelling the sex hormone-binding globulin-independent effects of BioT, the last two associations might be indirect. Conversely, obesity and android fat distribution were associated with elevated serum BioT. In men, higher BioT was associated with lower hip circumference and lower fasting glucose. Reciprocally, obesity was associated with lower BioT and higher E2, while upper-body fat distribution and raised triglycerides were associated with lower E2.
conclusionsAdipose tissue and metabolic dysfunction are associated with deranged sex hormone levels in both sexes. In women, elevated BioT might be a cause of obesity. Conversely, in men, higher BioT appears to have beneficial effects on adiposity and glucose metabolism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.