ArticleeLife2022
Global organization of neuronal activity only requires unstructured local connectivity.
Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Strong and localized recurrence controls the dimensionality of neural activity across brain areas.Nature neuroscience · 2026Article
- Cross-region neuron co-firing mediated by ripple oscillations supports distributed working memory representations.Nature neuroscience · 2026Article
- Stiefel Manifold Dynamical Systems for Tracking Representational Drift.bioRxiv : the preprint server for biology · 2026Article
- Continuous input drives motor cortical dynamics during reaching.Research square · 2026Article
- Article
- Cross-region neuron co-firing mediated by ripple oscillations supports distributed working memory representations.bioRxiv : the preprint server for biology · 2025Article
- Stochastic activity in low-rank recurrent neural networks.PLoS computational biology · 2025Article
- Developmental maturation of millimeter-scale functional networks across brain areas.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Reconciliation of weak pairwise spike-train correlations and highly coherent local field potentials across space.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Developmental maturation of millimeter-scale functional networks across brain areas.bioRxiv : the preprint server for biology · 2024Article
- Nonlinear manifolds underlie neural population activity during behaviour.bioRxiv : the preprint server for biology · 2024Article
- The selfish network: how the brain preserves behavioral function through shifts in neuronal network state.Trends in neurosciences · 2024Review
- Common modular architecture across diverse cortical areas in early development.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Article
- NNMT: Mean-Field Based Analysis Tools for Neuronal Network Models.Frontiers in neuroinformatics · 2022Article
- Spatial and temporal correlations in neural networks with structured connectivity.Physical review researchArticle
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Modern electrophysiological recordings simultaneously capture single-unit spiking activities of hundreds of neurons spread across large cortical distances. Yet, this parallel activity is often confined to relatively low-dimensional manifolds. This implies strong coordination also among neurons that are most likely not even connected. Here, we combine in vivo recordings with network models and theory to characterize the nature of mesoscopic coordination patterns in macaque motor cortex and to expose their origin: We find that heterogeneity in local connectivity supports network states with complex long-range cooperation between neurons that arises from multi-synaptic, short-range connections. Our theory explains the experimentally observed spatial organization of covariances in resting state recordings as well as the behaviorally related modulation of covariance patterns during a reach-to-grasp task. The ubiquity of heterogeneity in local cortical circuits suggests that the brain uses the described mechanism to flexibly adapt neuronal coordination to momentary demands.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.