Evidence map›Paper›PMID 35049144›Full record

ArticleImmunity, inflammation and disease2022

Profound thrombocytopenia associated with administration of multiple anti-inflammatory agents in baboons.

Mohamed H Bikhet, Christophe Hansen-Estruch, Mariyam Javed, Dalis E Collins, Jeremy B Foote, David Ayares, Hidetaka Hara, David K C Cooper

Open access · goldAbstract read
In one paragraph

Article in Immunity, inflammation and disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. The Evolution of Immunosuppressive Therapy in Pig-to-Nonhuman Primate Organ Transplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2024
    Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Mohamed H BikhetXenotransplantation Program, Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Christophe Hansen-EstruchXenotransplantation Program, Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Mariyam JavedXenotransplantation Program, Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Dalis E CollinsAnimal Resources Program, University of at Birmingham, Birmingham, Alabama, USA.
Jeremy B FooteDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
David AyaresRevivicor, Blacksburg, Virginia, USA.
Hidetaka HaraXenotransplantation Program, Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA.
David K C CooperXenotransplantation Program, Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA.
University of Alabama at Birmingham · USXenotran (United States) · US

Funding

Prolonging life-supported pig kidney and heart graft survival in baboons by suppressing inflammationU19AI090959 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI COOPER, DAVID KC · 2010 to 2024
$26.3M
NIAID NIH HHS U19 AI090959
6 · The paper itself

Abstract

Congestion, granular platelet debris both within macrophage and extracellularly, and neutrophil infiltration in the spleen of a baboon that was euthanized with profound thrombocytopenia.

Indexed as

ThrombocytopeniaAnimalsAnimals, Genetically ModifiedAnti-Inflammatory AgentsPapioTransplantation, HeterologousAnti-Inflammatory AgentsbaboonIL-6pigthrombocytopeniaxenotransplantation

Identifiers

PMID35049144
PMCPMC8926498
OpenAlexW4206560080

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.