ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2022
Stability in BMI over time is associated with a better cognitive trajectory in older adults.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 47 citations in OpenAlex.
- Midlife depressive symptoms, smoking status, hypertension, diabetes, dyslipidemia and obesity modify the association of long-term vascular risk factor variability from childhood with midlife cognitive function: The Bogalusa Heart Study.International journal of cardiology. Cardiovascular risk and prevention · 2026Article
- Associations between hearing and vision impairment and type 2 diabetes among middle-aged and older chinese adults: a nationwide longitudinal cohort study.Journal of health, population, and nutrition · 2026Observational
- Association of Long-Term Vascular Risk Factor Variability from Childhood and Midlife Cognitive Function: The Bogalusa Heart Study.Research square · 2026Article
- Impact of body roundness index on cognitive decline and cognitive impairment in middle-aged and older adults ≥ 45 years: mediating role of biological aging.Scientific reports · 2026Article
- The impact of slope-adjusted visit-to-visit body mass index variability on early dementia risk prediction.International journal of obesity (2005) · 2026Article
- Association between cumulative average BMI and cognitive decline: a 24-year cohort study.Journal of neurology · 2026Article
- Qualitative assessment of hepatic steatosis on modern grayscale ultrasound: more accurate than previously thought?Abdominal radiology (New York) · 2025Article
- Variability in body weight and body composition and cognitive trajectories in older adults in the United States.Obesity (Silver Spring, Md.) · 2025Article
- The association between cognitive domains and suicidal ideation in patients with mild dementia: the crucial role of judgement domain.BMC geriatrics · 2025Article
- Visit-to-visit body mass index variability in relation to longitudinal cognitive changes in Chinese adults: a retrospective cohort study.BMC public health · 2025Article
- Sex-specific association between body roundness index and cognitive impairment among hospitalized middle-aged and elderly patients with type 2 diabetes in China: a cross-sectional analysis.European journal of medical research · 2025Article
- The Nutritarian Women's Health Study (NWHS): Cohort 1.American journal of lifestyle medicine · 2025Article
- Body mass index changes and trajectories from midlife to late-life: association with subjective cognitive complaints in a 30-year Women's cohort study.Age and ageing · 2025Article
- Overweight in mediating the association between depression and new-onset diabetes: A population-based research from Health and Retirement Study.World journal of diabetes · 2025Article
- Trajectories of general and central obesity beyond middle age in relation to late-life cognitive decline and dementia.Obesity (Silver Spring, Md.) · 2025Article
- Association of a modified body shape index with cognitive impairment in middle-aged and elderly Chinese adults: a cross-sectional analysis from CHARLS.Frontiers in nutrition · 2025Article
- Global Burden of Alzheimer's disease and other dementias in adults aged 65 years and older, 1991-2021: population-based study.Frontiers in public health · 2025Article
- The mediating role of coping style in the relationship between optimism and cognitive impairment in patients with stroke.Frontiers in neurology · 2025Article
- Dynamic relations between longitudinal morphological, behavioral, and emotional indicators and cognitive impairment: evidence from the Chinese Longitudinal Healthy Longevity Survey.BMC public health · 2024Article
- Exploring the relationship between lipid metabolism and cognition in individuals living with stable-phase Schizophrenia: a small cross-sectional study using Olink proteomics analysis.BMC psychiatry · 2024Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveEvidence on simultaneous changes in body mass index (BMI) and cognitive decline, which better reflect the natural course of both health phenomena, is limited.
methodsWe capitalized on longitudinal data from 15,977 initially non-demented elderly from the Alzheimer's Disease Centers followed for 5 years on average. Changes in BMI were defined as (1) last minus first BMI, (2) mean of all follow-up BMIs minus first BMI, and (3) standard deviation of BMI change from baseline and all follow-up visits (representing variability).
resultsParticipants with significant changes in BMI (increase or decrease of ≥5%), or who had greater variability in BMI, had faster cognitive decline. This pattern was consistent irrespective of normal (BMI < 25; N = 5747), overweight (25 ≤ BMI < 30; N = 6302), or obese (BMI ≥ 30; N = 3928) BMI at baseline.
conclusionsStability in BMI predicts better cognitive trajectories suggesting clinical value in tracking BMI change, which is simple to measure, and may point to individuals whose cognition is declining.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.