A method for time-independent film dosimetry: Can we obtain accurate patient-specific QA results at any time postirradiation?

aimThe aim of this work was twofold. (1) To investigate and present a comparison between EBT3 and EBT-XD in terms of postirradiation color changes. (2) Create an automated workflow to allow radiochromic film (EBT3/XD) to be scanned and converted to dose accurately at any postirradiation time. MATERIALS AND

methodsTen GafChromic EBT-XD calibration films were exposed in 2 Gy increments up to 18 Gy. Calibrates were then scanned at 5-min intervals postirradiation over 24 h using an AutoHotKey script, resulting in 288 TIFF images. Following the 24-h scanning period, a MATLAB script was used to automatically read the tiff images and create a series of 288 calibration curves distinct in time which is termed as the "Temporal Calibration Model" (TCM). The model is saved as a series of polynomial fit coefficients to net optical density as a function of dose, timestamped in 5-min increments. Ten patient-specific film measurements (5 × EBT-XD and 5 × EBT3) were then carried out and scanned using the same 5-min scan intervals from 5 min postirradiation to 24 h postirradiation. The TCM was then automatically applied using eFilmQA software to convert the patient-specific QA films to dose by applying the relevant calibration curve from the TCM, corresponding to the arbitrary postirradiation time that the film was scanned. Each dose plane at postirradiation scan intervals of 5 min up to 20 h was then compared to the ground-truth dose plane using gamma analysis.

resultsGamma pass rates using the TCM at time t, normalized to the pass rate after 20 h postirradiation, were found to have a maximum coefficient of variation of 3% over any postirradiation time. Conversely, not using the TCM resulted in coefficients of variation of up to 39%. Clinical implementation of this method showed an average accuracy of 2.8% when comparing the clinical result to the TCM result.

conclusionsWe have developed a methodology that allows radiochromic film to be accurately used as a dosimeter at any arbitrary scan postirradiation time, whereas previously, waiting periods of 16-24 h before readout were needed to ensure the postirradiation changes had stabilized. The creation of a TCM can enable results from radiochromic film measurements to be obtained quickly postirradiation. Using a conventional single calibration curve generated at 20 h postirradiation can result in gamma pass-rate difference of up to 75% for measurement films scanned at a much shorter postirradiation time.