ArticleThe British journal of psychiatry : the journal of mental science2022
Anxiety disorders and age-related changes in physiology.
Article in The British journal of psychiatry : the journal of mental science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- Metabolomic ageing across mental and behavioural disorders.BMJ mental health · 2026Article
- Article
- Difficulties in emotion regulation and exercise addiction among retired adults: the mediating roles of state anxiety and social dependence.Frontiers in psychology · 2026Article
- Anxiety and hypertension in young and middle-aged adults: a longitudinal cohort study.Journal of public health (Oxford, England) · 2025Article
- Metabolomic age (MileAge) predicts health and life span: A comparison of multiple machine learning algorithms.Science advances · 2024Article
- Association between obesity and sleep disorder in the elderly: evidence from NHANES 2005-2018.Frontiers in nutrition · 2024Article
- Preliminary evidence for altered brain-heart coherence during anxiogenic movies.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Telomere Length Associations With Clinical Diagnosis, Age, and Polygenic Risk Scores for Anxiety Disorder, Depression, and Bipolar Disorder.Biological psychiatry global open science · 2023Article
- Anxiety disorders are associated with reduced bone mineral density in men: Findings from the Geelong Osteoporosis Study.Acta psychiatrica Scandinavica · 2023Article
- Anxiety and Depression in People with Eczema or Psoriasis: A Comparison of Associations in UK Biobank and Linked Primary Care Data.Clinical epidemiology · 2023Article
- Frailty in individuals with depression, bipolar disorder and anxiety disorders: longitudinal analyses of all-cause mortality.BMC medicine · 2022Article
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Authors and funding
4 authors at 2 institutions in 3 countries.
Funding
Abstract
backgroundAnxiety disorders are leading contributors to the global disease burden, highly prevalent across the lifespan and associated with substantially increased morbidity and early mortality.
aimsThe aim of this study was to examine age-related changes across a wide range of physiological measures in middle-aged and older adults with a lifetime history of anxiety disorders compared with healthy controls.
methodThe UK Biobank study recruited >500 000 adults, aged 37-73, between 2006 and 2010. We used generalised additive models to estimate non-linear associations between age and hand-grip strength, cardiovascular function, body composition, lung function and heel bone mineral density in a case group and in a control group.
resultsThe main data-set included 332 078 adults (mean age 56.37 years; 52.65% females). In both sexes, individuals with anxiety disorders had a lower hand-grip strength and lower blood pressure, whereas their pulse rate and body composition measures were higher than in the healthy control group. Case-control group differences were larger when considering individuals with chronic and/or severe anxiety disorders, and differences in body composition were modulated by depression comorbidity status. Differences in age-related physiological changes between females in the anxiety disorder case group and healthy controls were most evident for blood pressure, pulse rate and body composition, whereas this was the case in males for hand-grip strength, blood pressure and body composition. Most differences in physiological measures between the case and control groups decreased with increasing age.
conclusionsFindings in individuals with a lifetime history of anxiety disorders differed from a healthy control group across multiple physiological measures, with some evidence of case-control group differences by age. The differences observed varied by chronicity/severity and depression comorbidity.
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