Evidence map›Paper›PMID 35048603›Full record

ArticleSichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition2022

[Anti-Tumor Effect of a Novel Oncolytic Virus Based on Chimpanzee Adenovirus Type 6].

Qi Wang, Yi-Han Wang, Ying Li, Man Xing, Dong-Ming Zhou

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Qi WangDepartment of Pathogenic Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China.
Yi-Han WangDepartment of Pathogenic Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China.
Ying LiDepartment of Pathogenic Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China.
Man XingDepartment of Pathogenic Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China.
Dong-Ming ZhouDepartment of Pathogenic Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China.
Tianjin Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo construct, with chimpanzee adenovirus serotype 6 (AdC6) as the vector, a novel oncolytic adenovirus, enabling it to selectively replicate intratumorally, to test its tumor suppressive effect

methodsBased on the AdC6 vector, the human telomerase reverse transcriptase (hTERT) promoter was used to drive the expression of E1A, the adenovirus replication-related gene, and the recombinant oncolytic virus AdC6-htertΔE1A-ΔE3 was thus obtained. The oncolytic virus AdC6-htertE1A-ΔE3 (CSF

resultsRestriction digestion revealed that the oncolytic viruses AdC6-htertE1A-ΔE3, AdC6-htertE1A-ΔE3 (CSF

conclusionOncolytic virus based on AdC6 could eliminate tumor

Indexed as

Oncolytic VirotherapyOncolytic VirusesAdenoviridaeAnimalsCell Line, TumorGenetic VectorsHEK293 CellsHeLa CellsHumansMaleMiceMice, Inbred C57BLPan troglodytesVirus ReplicationChimpanzee adenovirus type 6Human telomerase reverse transcriptase promoterOncolytic virus

Identifiers

PMID35048603
PMCPMC10408869
OpenAlexW4206814037

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.