ReviewSichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition2022
[Regulation of ILC3/Th17-Mediated Intestinal Immune Response by Circadian Rhythm].
Review in Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 2 citations in OpenAlex.
- Circadian rhythm-guided cellular therapy in hematologic malignancies: mechanisms, clinical evidence, and optimization strategies.Biomarker research · 2026Review
- Gut microbiota, circadian rhythms and their interactions: implications for the pathogenesis and treatment of depression.Annals of medicine · 2025Review
- Circadian rhythm regulates the function of immune cells and participates in the development of tumors.Cell death discovery · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The circadian rhythm is a widely-recognized phenomenon, according to which the life activities of organisms change periodically, synchronizing with the day and night cycles. The activities of the immune system are also regulated by the circadian rhythm. Group 3 innate lymphoid cells (ILC3s) and T helper 17 (Th17) cells (ILC3/Th17) are the innate and adaptive subsets of immune cells mediating type 17 immune response, which is featured by the expression of transcription factor retinoid orphan receptor gamma t (RORγt) and the production of interleukin (IL)-17 and IL-22. The processes of type 17 immune response are completed mainly through the participation of ILC3/Th17 and are closely associated with the intestinal immune response. Recent studies have found that the immune response mediated by ILC3/Th17 is intricately regulated by the circadian rhythm through molecular mechanisms controlling the circadian rhythm, or through other external factors that change according to the light-darkness cycle, for example the food intake rhythm. The secretion of cytokines changes along with the regulatory effect of circadian rhythm on ILC3/Th17, which in turn impacts, to a certain degree, on the onset and development of intestinal inflammatory diseases, including bacterial infection and autoimmune diseases. The understanding of mechanisms regulating ILC3/Th17 responses by the circadian rhythm may promote better understanding of the course of action of the immune system and facilitate the development and discovery of potential targets for treatment of intestinal inflammatory diseases.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.