Evidence map›Paper›PMID 35048549›Full record

ArticleObesity (Silver Spring, Md.)2022

Gut microbiome and diet in populations with obesity: Role of the Na+/K+-ATPase transporter signaling in severe COVID-19.

Zeid J Khitan, Khew-Voon Chin, Komal Sodhi, Murad Kheetan, Ahlim Alsanani, Joseph I Shapiro

Open access · greenAbstract read
In one paragraph

Article in Obesity (Silver Spring, Md.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Zeid J KhitanDepartment of Internal Medicine, Joan C. Edwards School of Medicine, Marshall University, Huntington, West Virginia, USA.ORCID 0000-0003-1607-770X
Khew-Voon ChinDepartment of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, West Virginia, USA.ORCID 0000-0003-3572-6605
Komal SodhiDepartment of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, West Virginia, USA.ORCID 0000-0002-1179-2985
Murad KheetanDepartment of Internal Medicine, Joan C. Edwards School of Medicine, Marshall University, Huntington, West Virginia, USA.
Ahlim AlsananiDepartment of Internal Medicine, Joan C. Edwards School of Medicine, Marshall University, Huntington, West Virginia, USA.
Joseph I ShapiroDepartment of Internal Medicine, Joan C. Edwards School of Medicine, Marshall University, Huntington, West Virginia, USA.
Marshall University · US

Funding

CORAL: Clinical Coordinating CenterU01HL071556 · NHLBI · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI COOPER, CHRISTOPHER J · 2004 to 2013
$19.3M
Receptor Na/K-ATPase Antagonists As Novel Therapeutics For Renal/Cardiac DiseasesR01HL109015 · NHLBI · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI SHAPIRO, JOSEPH ISAAC, XIE, ZIJIAN · 2011 to 2014
$2.2M
Na/K-ATPase Reduction in Renal Disease-Related Cardiac DysfunctionR01HL105649 · NHLBI · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI TIAN, JIANG · 2012 to 2016
$1.8M
EMC10, a novel obesity-regulated circulating factor, regulates energy and metabolic homeostasisR01DK109015 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LIEW, CHONG WEE · 2016 to 2020
$1.8M
NHLBI NIH HHS R01 HL105649NHLBI NIH HHS R01 HL109015NHLBI NIH HHS U01 HL071556NIDDK NIH HHS HL071556NIDDK NIH HHS HL105649NIDDK NIH HHS HL109015
6 · The paper itself

Abstract

objectiveThe triad of obesity, a high-protein diet from animal sources, and disturbed gut microbiota have been linked to poor clinical outcomes in patients with COVID-19. In this report, the effect of oxidative stress resulting from the Na

methodsProtein-protein interactions with the SARS-CoV-2 proteome were identified from the interactome data for Na

resultsThe ATP1A1 subunit of the Na

conclusionsThe similarities between the effects of SARS-CoV-2 proteins and indoxyl sulphate on the Na

Indexed as

COVID-19Gastrointestinal MicrobiomeAnimalsDietHumansObesitySARS-CoV-2Sodium-Potassium-Exchanging ATPaseSodium-Potassium-Exchanging ATPase

Identifiers

PMID35048549
PMCPMC8957587
OpenAlexW4206812612

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.