Evidence map›Paper›PMID 35048545›Full record

ArticleESC heart failure2022

Cardiac MRI predictors of adverse outcomes in adults with a systemic right ventricle.

Matthew J Lewis, Alexandra Van Dissel, Jonathan Kochav, Michael P DiLorenzo, Jonathan Ginns, Noa Zemer-Wassercug, Maarten Groenink, Barbara Mulder, Marlon Rosenbaum

Open access · goldAbstract read
In one paragraph

Article in ESC heart failure, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Longitudinal changes in systemic right ventricular remodeling in adult patients with transposition of the great vessels as assessed by cardiovascular magnetic resonance imaging.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2024
    Article
  8. The Right Heart in Congenital Heart Disease.Current heart failure reports · 2023
    Review
  9. Novel Approaches to the Failing Congenital Heart.Current cardiology reports · 2023
    Review
  10. Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Matthew J LewisDivision of Cardiology, Department of Medicine, Schneeweiss Adult Congenital Heart Center, Columbia University Medical Center, New York, NY, USA.
Alexandra Van DisselDivision of Cardiology, Amsterdam University Medical Center, Amsterdam, The Netherlands.
Jonathan KochavDivision of Cardiology, Department of Medicine, Schneeweiss Adult Congenital Heart Center, Columbia University Medical Center, New York, NY, USA.
Michael P DiLorenzoDivision of Pediatric Cardiology, Department of Pediatrics, NewYork-Presbyterian/Morgan Stanley Children's Hospital, Columbia University Irving Medical Center, New York, NY, USA.
Jonathan GinnsAustin Heart, Austin, TX, USA.
Noa Zemer-WassercugDivision of Cardiology, Department of Medicine, Schneeweiss Adult Congenital Heart Center, Columbia University Medical Center, New York, NY, USA.
Maarten GroeninkDivision of Cardiology, Amsterdam University Medical Center, Amsterdam, The Netherlands.
Barbara MulderDivision of Cardiology, Amsterdam University Medical Center, Amsterdam, The Netherlands.
Marlon RosenbaumDivision of Cardiology, Department of Medicine, Schneeweiss Adult Congenital Heart Center, Columbia University Medical Center, New York, NY, USA.
Amsterdam University Medical Centers · NLAdult Congenital Heart Association · USColumbia University Irving Medical Center · USMorgan Stanley Children's Hospital · USThe University of Texas at Austin · US

Funding

The Association of Damaging Genetic Variation With Ventricular Function in Hypoplastic Left Heart SyndromeK23HL143136 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LEWIS, MATTHEW · 2018 to 2022
$907k
NHLBI NIH HHS K23 HL143136
6 · The paper itself

Abstract

aimsPredicting risk in individuals with a systemic right ventricle (SRV) remains difficult. We assessed the value of cardiac MRI (CMR) for predicting death, heart transplantation (HT), or need for a ventricular assist device (VAD) in adults with D-transposition of the great arteries (DTGA) post Mustard/Senning and in adults with congenitally corrected transposition of the great arteries (ccTGA) at two large academic centres. METHODS AND

resultsBetween December 1999 and November 2020, 158 adult patients with an SRV underwent CMR. Indexed right ventricular end-diastolic volume (RVEDVI), indexed right ventricular end-systolic volume (RVESVI), right ventricular ejection fraction (RVEF), and right ventricular mass (RV mass) were determined by a core laboratory. Receiver operating curves, area under the curve (AUC), and cut-points maximizing sensitivity and specificity for the endpoint for each CMR parameter were calculated. Over a median of 8.5 years, 21 patients (13%) met a combined endpoint of HT referral, VAD, or death. Each CMR parameter was significantly associated with the endpoint in both cohorts. The AUCs for RVEDVI, RVESVI, RVEF, and RV mass to predict the endpoint were 0.93, 0.90, 0.73, and 0.84 for DTGA and 0.76, 0.74, 0.71, and 0.74 for ccTGA, respectively. Optimized cut-points for RVEDVI were calculated for DTGA and ccTGA and were 132 and 126 mL/m

conclusionsCardiac MRI parameters are associated with an increased risk of death, HT, or VAD in patients with an SRV and should be considered to facilitate risk stratification.

Indexed as

Transposition of Great VesselsVentricular Dysfunction, RightAdultHeart VentriclesHumansMagnetic Resonance ImagingStroke VolumeVentricular Function, RightAdult congenital heart diseaseCardiac MRIHeart failureHeart transplantSystemic right ventricleTransposition of the great arteries

Identifiers

PMID35048545
PMCPMC8934915
OpenAlexW4206660060

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.