Evidence map›Paper›PMID 35048374›Full record

Observational studyJPEN. Journal of parenteral and enteral nutrition2022

Specific nutrition and metabolic characteristics of critically ill patients with persistent COVID-19.

Marina V Viana, Olivier Pantet, Mélanie Charrière, Doris Favre, Lise Piquilloud, Antoine G Schneider, Claire-Anne Hurni, Mette M Berger

Open access · hybridAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in JPEN. Journal of parenteral and enteral nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. αInternational journal of molecular sciences · 2023
    Review
  4. Article
  5. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Marina V VianaService of Adult Intensive Care Medicine, Lausanne University Hospital (CHUV), Lausanne, Switzerland.
Olivier PantetService of Adult Intensive Care Medicine, Lausanne University Hospital (CHUV), Lausanne, Switzerland.ORCID 0000-0002-6195-8947
Mélanie CharrièreService of Adult Intensive Care Medicine, Lausanne University Hospital (CHUV), Lausanne, Switzerland.ORCID 0000-0002-0669-0343
Doris FavreService of Adult Intensive Care Medicine, Lausanne University Hospital (CHUV), Lausanne, Switzerland.
Lise PiquilloudService of Adult Intensive Care Medicine, Lausanne University Hospital (CHUV), Lausanne, Switzerland.ORCID 0000-0002-4226-8772
Antoine G SchneiderService of Adult Intensive Care Medicine, Lausanne University Hospital (CHUV), Lausanne, Switzerland.ORCID 0000-0003-0576-7094
Claire-Anne HurniService of Adult Intensive Care Medicine, Lausanne University Hospital (CHUV), Lausanne, Switzerland.
Mette M BergerService of Adult Intensive Care Medicine, Lausanne University Hospital (CHUV), Lausanne, Switzerland.ORCID 0000-0001-5427-1648
University Hospital of Lausanne · CHUniversidade Federal do Rio Grande do Sul · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLittle is known about metabolic and nutrition characteristics of patients with coronavirus disease 2019 (COVID-19) and persistent critical illness. We aimed to compare those characteristics in patients with PCI and COVID-19 and patients without COVID-19 infection (non-CO)-primarily, their energy balance.

methodsThis is a prospective observational study including two consecutive cohorts, defined as needing intubation for >10 days. We collected demographic data, severity scores, nutrition variables, length of stay, and mortality.

resultsAltogether, 104 patients (52 per group) were included (59 ± 14 years old [mean ± SD], 75% men) between July 2019 and May 2020. SAPSII, Nutrition Risk Screening (NRS) score, proportion of obese patients, duration of intubation (18.2 ± 11.7 days), and mortality rates were similar. Patients with COVID-19 (vs non-CO) had lower SOFA scores (P = 0.013) and more frequently needed prone position (P < 0.0001) and neuromuscular blockade (P < 0.0001): lengths of ICU (P = 0.03) and hospital stays were shorter (P < 0.0001). Prescribed energy targets were below those of the ICU protocol. The energy balance of patients with COVID-19 was significantly more negative after day 10. Enteral nutrition (EN) started earlier (P < 0.0001). During the first 10 days, COVID-19 patients received more lipid (propofol sedation) and less protein. Higher admission C-reactive protein (P = 0.002) decreased faster (P < 0.001). Whereas intestinal function was characterized by constipation in both groups during the first 10 days, diarrhea was less common in patients with COVID-19 thereafter.

conclusionCompared with non-CO patients, COVID-19 patients were not more obese, had lower SOFA scores, and were fed more rapidly with EN, because of a more normal gastrointestinal function possibly due to fewer non-respiratory organ failures: their energy balances were more negative after the first 10 days. Propofol sedation reduced protein delivery.

Indexed as

COVID-19Percutaneous Coronary InterventionPropofolAgedCritical IllnessEnergy IntakeFemaleHumansIntensive Care UnitsMaleMiddle AgedObesityPropofolenergy deficitgastrointestinal functionhypophosphatemialipidpropofolproteinrefeeding syndrome riskunderfeeding

Identifiers

PMID35048374
PMCPMC9015259
OpenAlexW4205129343

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.