Evidence map›Paper›PMID 35048361›Full record

ArticleJournal of the American Geriatrics Society2022

The association of walking pace and incident heart failure and subtypes among postmenopausal women.

Moafi-Madani Miremad, Xiaochen Lin, Somwail Rasla, Amr El Meligy, Mary B Roberts, Deepika Laddu, Matthew Allison, Lisa W Martin, Aladdin H Shadyab, Jo Ann E Manson and 5 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Geriatrics Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 2 countries.

Moafi-Madani MiremadDepartment of Epidemiology, Brown University, Providence, Rhode Island, USA.ORCID 0000-0002-2942-0696
Xiaochen LinDepartment of Epidemiology, Brown University, Providence, Rhode Island, USA.
Somwail RaslaDivision of General Internal Medicine, Brown University, Providence, Rhode Island, USA.
Amr El MeligyDivision of General Internal Medicine, Brown University, Providence, Rhode Island, USA.ORCID 0000-0002-3053-0024
Mary B RobertsCenter for Primary Care and Prevention, Care New England Medical Group/Primary Care and Specialty Services, Pawtucket, Rhode Island, USA.
Deepika LadduDepartment of Physical Therapy, University of Illinois at Chicago, Chicago, Illinois, USA.ORCID 0000-0001-6790-0220
Matthew AllisonDepartment of Family Medicine and Public Health, University of California San Diego, La Jolla, California, USA.
Lisa W MartinDepartment of Medicine, George Washington University, Washington, District of Columbia, USA.
Aladdin H ShadyabDepartment of Family Medicine and Public Health, University of California San Diego, La Jolla, California, USA.
Jo Ann E MansonDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Rowan ChlebowskiDivision of Medical Oncology and Hematology, University of California Los Angeles, Los Angeles, California, USA.
Gurusher PanjrathDepartment of Medicine, George Washington University, Washington, District of Columbia, USA.
Michael J LaMonteDepartment of Epidemiology and Environmental Health, University of Buffalo, Buffalo, New York, USA.
Simin LiuDepartment of Epidemiology, Brown University, Providence, Rhode Island, USA.
Charles B EatonDepartment of Epidemiology, Brown University, Providence, Rhode Island, USA.
Brown University · USGeorge Washington University · USRhode Island Department of Health · USUniversity of California San Diego · USBrigham and Women's Hospital · USUniversity at Buffalo, State University of New York · USUniversity of California, Los Angeles · USUniversity of Illinois Chicago · US

Funding

WHISH-2-Prevent Heart Failure StudyR01HL130591 · NHLBI · MEMORIAL HOSPITAL OF RHODE ISLAND · PI EATON, CHARLES B · 2016 to 2020
$3.1M
The impact of a resistance training intervention on blood pressure control in older adults with SarcopeniaK01HL148503 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LADDU, DEEPIKA · 2019 to 2023
$901k
NHLBI NIH HHS HHSN268201600001CNHLBI NIH HHS HHSN268201600002CNHLBI NIH HHS HHSN268201600003CNHLBI NIH HHS HHSN268201600004CNHLBI NIH HHS HHSN268201600018CNHLBI NIH HHS K01 HL148503NHLBI NIH HHS R01 HL130591
6 · The paper itself

Abstract

backgroundTo investigate the association between walking pace and the risk of heart failure (HF) and HF sub-types.

methodsWe examined associations of self-reported walking pace with risk of incident HF and HF subtypes of preserved (HFpEF) and reduced (HFrEF) ejection fractions, among 25,183 postmenopausal women, ages 50-79 years. At enrollment into the Women's Health Initiative cohort in 1993-1998, this subset of women was free of HF, cancer, or the inability to walk one block, with self-reported information on walking pace and walking duration. Multivariable Cox regression was used to examine associations of walking pace (casual <2 mph [referent], average 2-3 mph, and fast >3 mph) with incident HF. We also examined the joint association of walking pace and duration with incident HF.

resultsThere were 1455 incident adjudicated acute decompensated HF hospitalization cases during a median of 16.9 years of follow-up. There was a strong inverse association between walking pace and overall risk of HF (HR = 0.73, 95% CI [0.65, 0.83] for average vs. casual walking; HR = 0.66, 95%CI [0.56, 0.78] for fast vs. casual walking). There were similar associations of walking pace with HFpEF (HR = 0.73, 95%CI [0.62, 0.86] average vs. casual; HR = 0.63, 95%CI [0.50, 0.80] for fast vs. casual) and with HFrEF (HR = 0.72, 95%CI [0.57, 0.91] for average vs. casual; HR = 0.74, 95%CI [0.54, 0.99] for fast vs. casual). The risk of HF associated with fast walking with less than 1 h/week walking duration was comparable with the risk of HF among casual and average walkers with more than 2 h/week walking duration.

conclusionWalking pace was inversely associated with risks of overall HF, HFpEF, and HFrEF in postmenopausal women. Whether interventions to increase the walking pace in older adults will reduce HF risk and whether fast pace will compensate for the short duration of walking warrants further study.

Indexed as

Heart FailureAgedFemaleHumansPostmenopausePrognosisRisk FactorsStroke VolumeVentricular Function, LeftWalking Speedheart failurephysical activitypostmenopausalwalking pacewomen

Identifiers

PMID35048361
PMCPMC10275503
OpenAlexW4205584848

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.