Evidence map›Paper›PMID 35048327›Full record

ArticleProbiotics and antimicrobial proteins2023

Heat-Killed Levilactobacillus brevis as a Candidate Postbiotics Through Immunostimulation Mediated by Macrophage-Inducible C-Type Lectin.

Tomoyuki Shimazu, Mai Suzuki, Ryo Takasaki, Asuka Besshi, Yuna Suzuki, Yoichiro Iwakura

Abstract read
PubMed Publisher
In one paragraph

Article in Probiotics and antimicrobial proteins, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Tomoyuki ShimazuDepartment of Food, Agriculture and Environment, Miyagi University, Sendai, 982-0215, Japan. shimadut@myu.ac.jp.ORCID 0000-0003-3384-6371
Mai SuzukiDepartment of Food, Agriculture and Environment, Miyagi University, Sendai, 982-0215, Japan.
Ryo TakasakiDepartment of Food, Agriculture and Environment, Miyagi University, Sendai, 982-0215, Japan.
Asuka BesshiDepartment of Food, Agriculture and Environment, Miyagi University, Sendai, 982-0215, Japan.
Yuna SuzukiDepartment of Food, Agriculture and Environment, Miyagi University, Sendai, 982-0215, Japan.
Yoichiro IwakuraCenter for Animal Disease Models, Research Institute for Biomedical Science, Tokyo University of Science, Chiba, Japan.
Miyagi University · JPTokyo University of Science · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To understand the beneficial health-promoting effects of lactic acid bacteria (LAB) on immune cells, it is necessary to understand the relationship between LAB and innate immune receptors. We investigated the possible involvement of C-type lectin receptors (CLRs) in the immune-stimulating function of LAB in several strains. We found that levels of interleukin (IL)-6, tumor necrosis factor (TNF)-α, and IL-10 were reduced by the addition of inhibitors for spleen tyrosine kinase (syk), a signaling molecule used by several CLRs. Furthermore, employing CLR-Fc fusion proteins and reporter cells, we found that macrophage-inducible C-type lectin (Mincle) binds to Levilactobacillus brevis strain La37. Interestingly, this interaction was only observed in heat-killed L. brevis and disappeared after proteinase K treatment. Seven strains of L. brevis from different sources were also examined; among them, six strains showed Mincle reactivity, and the characteristics of the ligand were similar to those of La37. These results may facilitate a better understanding of the immunomodulatory effects of LAB for the development of functional foods.

Indexed as

Levilactobacillus brevisHot TemperatureImmunizationInterleukin-6Lectins, C-TypeMacrophagesInterleukin-6Lectins, C-TypeC-type lectin receptorsInnate immunityLactic acid bacteriaMincle

Identifiers

PMID35048327
OpenAlexW4206029994

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.