Evidence map›Paper›PMID 35048179›Full record

ArticleEuropean journal of pediatrics2022

Body mass index in type 2 spinal muscular atrophy: a longitudinal study.

Gloria Ferrantini, Giorgia Coratti, Roberta Onesimo, Simona Lucibello, Sarah Bompard, Ida Turrini, Graziamaria Cicala, Michela Caprarelli, Maria Carmela Pera, Chiara Bravetti and 16 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Body Weight and Range of Motion as Predictors of Trunk Asymmetry in Children With Spinal Muscular Atrophy: A Prospective Functional Assessment.Medical science monitor : international medical journal of experimental and clinical research · 2025
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 8 institutions in 1 country.

Gloria FerrantiniPediatric Neurology, Università Cattolica del Sacro Cuore, Rome, Italy.
Giorgia CorattiPediatric Neurology, Università Cattolica del Sacro Cuore, Rome, Italy.
Roberta OnesimoPediatric Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Simona LucibelloPediatric Neurology, Università Cattolica del Sacro Cuore, Rome, Italy.
Sarah BompardPediatric Neurology, Università Cattolica del Sacro Cuore, Rome, Italy.
Ida TurriniPediatric Neurology, Università Cattolica del Sacro Cuore, Rome, Italy.
Graziamaria CicalaPediatric Neurology, Università Cattolica del Sacro Cuore, Rome, Italy.
Michela CaprarelliPediatric Neurology, Università Cattolica del Sacro Cuore, Rome, Italy.
Maria Carmela PeraPediatric Neurology, Università Cattolica del Sacro Cuore, Rome, Italy.
Chiara BravettiPediatric Neurology, Università Cattolica del Sacro Cuore, Rome, Italy.
Beatrice BertiCentro Clinico Nemo, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Valentina GiorgioPediatric Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Claudio BrunoCenter of Experimental and Translational Myology, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Noemi BrolattiCenter of Experimental and Translational Myology, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Chiara PanicucciCenter of Experimental and Translational Myology, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Adele D'AmicoUnit of Neuromuscular and Neurodegenerative Disorders, Department of Neurosciences, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.
Antonella LongoUnit of Neuromuscular and Neurodegenerative Disorders, Department of Neurosciences, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.
Chiara LeoniPediatric Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Valeria A SansoneNeurorehabilitation Unit, University of Milan, Neuromuscular Omnicentre Clinical Center, Niguarda Hospital, Milan, Italy.
Emilio AlbamonteNeurorehabilitation Unit, University of Milan, Neuromuscular Omnicentre Clinical Center, Niguarda Hospital, Milan, Italy.
Sonia MessinaDepartment of Clinical and Experimental Medicine and Centro Clinico Nemo Sud, University of Messina, Messina, Italy.
Maria SframeliDepartment of Clinical and Experimental Medicine and Centro Clinico Nemo Sud, University of Messina, Messina, Italy.
Enrico BertiniUnit of Neuromuscular and Neurodegenerative Disorders, Department of Neurosciences, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.
Marika PanePediatric Neurology, Università Cattolica del Sacro Cuore, Rome, Italy.
Eugenio MercuriPediatric Neurology, Università Cattolica del Sacro Cuore, Rome, Italy. eugeniomaria.mercuri@unicatt.it.
Italian ISMAC study group
Agostino Gemelli University Polyclinic · ITUniversità Cattolica del Sacro Cuore · ITBambino Gesù Children's Hospital · ITIstituto Giannina Gaslini · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITUniversity of Messina · ITUniversity of Milan · ITCentro Clinico Nemo · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this retrospective study was to review body mass index (BMI) in a large cohort of Italian pediatric type 2 spinal muscular atrophy (SMA) patients, aged between 0 and 20 years and to establish possible differences in relation to a number of variables such as ventilation, motor function, and survival motor neuron 2 gene copies. Cross-sectional data were collected from 102 patients for a total of 344 visits. Standard growth charts for height and weight were used as reference, with age adjusted BMI calculated using the Center for Disease and Prevention Children's BMI Tool. In the 344 visits, weight ranged between 3.90 and 83 kg, and the BMI between 8.4 and 31.6 with a BMI/age z-scores <  - 2SD present in 28% and BMI/age z-scores >  + 2SD in 9% of the measurements. The BMI/age z-scores were relatively stable < 5 years of age with an increasing number of patients <  - 2SD after the age of 5, and a wider range of BMI/age z-scores after the age of 13. A difference on the BMI/age z-scores was found among the different age subgroups (< 5, 5-12, ≥ 13 years). A multivariate analysis in 58 patients with longitudinal assessments showed that baseline BMI/age z-scores and gender were significantly contributing to the changes while other variables were not.

conclusionOur results confirm that careful surveillance of weight and BMI/age z-scores is needed in type 2 SMA. Further studies, including assessments of chewing and swallowing and of lean/fat body mass, will help to better understand the possible mechanisms underlying weight issues. WHAT IS KNOWN: • Feeding difficulties have been reported in a few studies and were invariably found in patients with type 1 SMA. • Type 2 SMA patients often have low BMI with a relevant number of patients requiring tube feeding. WHAT IS NEW: • Reduction in BMI/age z-score overtime appeared to depend on baseline BMI/age z-score and gender. • Patients with a low BMI/age z-score were at higher risk of developing further reduction.

Indexed as

Muscular Atrophy, SpinalAdolescentAdultBody Mass IndexBody WeightChildChild, PreschoolCross-Sectional StudiesHumansInfantInfant, NewbornLongitudinal StudiesRetrospective StudiesYoung AdultBody mass indexChildrenNeonateNutritional statusSpinal muscular atrophy

Identifiers

PMID35048179
PMCPMC9056453
OpenAlexW4206287619

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.