Evidence map›Paper›PMID 35048156›Full record

Trial reportDiabetologia2022

Effects of progressive resistance training in individuals with type 2 diabetic polyneuropathy: a randomised assessor-blinded controlled trial.

Karolina S Khan, Kristian Overgaard, Hatice Tankisi, Pall Karlsson, Louise Devantier, Søren Gregersen, Troels S Jensen, Nanna B Finnerup, Rodica Pop-Busui, Ulrik Dalgas and 1 more

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Diabetologia, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03252132 (Resistance Training in Patients With Diabetic Neuropathy), which is not on this map. Cited by 19 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 6 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03252132 nacompletednot on this map

Resistance Training in Patients With Diabetic Neuropathy

TypeinterventionalSponsorDanish Pain Research CenterRan2017 to 2019Enrolled109ConditionsDiabetes Mellitus, Type 2, Polyneuropathy Diabetes, Diabetes Complications, Diabetic Peripheral NeuropathyArms12-week resistance training
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 6 syntheses or guidelines pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Review
  17. Review
  18. Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Karolina S KhanDepartment of Neurology, Aarhus University Hospital, Aarhus, Denmark. kasnop@rm.dk.ORCID 0000-0003-1288-6227
Kristian OvergaardExercise Biology, Department of Public Health, Aarhus University, Aarhus, Denmark.ORCID 0000-0002-3204-509X
Hatice TankisiInternational Diabetic Neuropathy Consortium, Department of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark.ORCID 0000-0001-8495-9769
Pall KarlssonDanish Pain Research Center, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.ORCID 0000-0001-7082-9576
Louise DevantierDepartment of Oto-Rhino-Laryngology, Regional Hospital West Jutland, Holstebro, Denmark.ORCID 0000-0001-7811-4874
Søren GregersenSteno Diabetes Center Aarhus, Aarhus, Denmark.ORCID 0000-0002-1953-8631
Troels S JensenDepartment of Neurology, Aarhus University Hospital, Aarhus, Denmark.ORCID 0000-0002-3487-6380
Nanna B FinnerupDepartment of Neurology, Aarhus University Hospital, Aarhus, Denmark.ORCID 0000-0001-5541-0240
Rodica Pop-BusuiDivision of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-2042-1350
Ulrik DalgasExercise Biology, Department of Public Health, Aarhus University, Aarhus, Denmark.ORCID 0000-0003-4132-2789
Henning AndersenDepartment of Neurology, Aarhus University Hospital, Aarhus, Denmark.ORCID 0000-0002-9082-2694
Aarhus University · DKRegional Hospital West Jutland · DKSteno Diabetes Centers · DKUniversity of Michigan · US

Funding

NIDDK Diabetic Foot Consortium Clinical Research UnitU01DK119083 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RODICA BUSUI (POP-BUSUI), Crystal Murray Holmes · 2018 to 2026
$5.5M
NIDDK NIH HHS U01 DK119083
6 · The paper itself

Abstract

aims/hypothesisThe aim of this study was to evaluate the effects of progressive resistance training (PRT) on muscle strength, intraepidermal nerve fibre density (IENFD) and motor function in individuals with type 2 diabetic polyneuropathy (DPN) and to compare potential adaptations to those of individuals with type 2 diabetes without DPN and healthy controls.

methodsThis was an assessor-blinded trial conducted at the Neurology department, Aarhus University Hospital. Adults with type 2 diabetes, with and without DPN and healthy control participants were randomised to either supervised PRT or non-PRT for 12 weeks. Allocation was concealed by a central office unrelated to the study. The co-primary outcomes were muscle strength in terms of the peak torque of the knee and ankle extensors and flexors, and IENFD. Secondary outcome measures included the 6 min walk test (6MWT), five-time sit-to-stand test (FTSST) and postural stability index obtained by static posturography.

resultsA total of 109 individuals were enrolled in three groups (type 2 diabetes with DPN [n = 42], type 2 diabetes without DPN [n = 32] and healthy control [n = 35]). PRT resulted in muscle strength gains of the knee extensors and flexors in all three groups using comparative analysis (DPN group, PRT 10.3 ± 9.6 Nm vs non-PRT -0.4 ± 8.2 Nm; non-DPN group, PRT 7.5 ± 5.8 Nm vs non-PRT 0.6 ± 8.8 Nm; healthy control group, PRT 6.3 ± 9.0 Nm vs non-PRT -0.4 ± 8.4 Nm; p<0.05, respectively). Following PRT the DPN group improved the 6MWT (PRT 34.6 ± 40.9 m vs non-PRT 2.7 ± 19.6 m; p=0.001) and the FTSST (PRT -1.5 ± 2.2 s vs non-PRT 1.5 ± 4.6 s; p=0.02). There was no change in IENFD following PRT in any of the groups. CONCLUSIONS/

interpretationPRT improved muscle strength of the knee extensors and flexors and motor function in individuals with type 2 diabetic polyneuropathy at levels comparable with those seen in individuals with diabetes without DPN and healthy control individuals, while no effects were observed in IENFD.

trial registrationClinicalTrials.gov NCT03252132

fundingResearch reported in this paper is part of the International Diabetic Neuropathy Consortium (IDNC) research programme, supported by a Novo Nordisk Foundation Challenge Program grant (grant no. NNF14OC0011633) and Aarhus University.

Indexed as

Diabetes Mellitus, Type 2Diabetic NeuropathiesResistance TrainingAdultHumansMuscle StrengthDiabetic polyneuropathyExerciseMotor functionMuscle strengthProgressive resistance trainingSmall nerve fibre structure

Identifiers

PMID35048156
OpenAlexW4206349685

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.