Evidence map›Paper›PMID 35048106›Full record

ReviewEuropean heart journal. Cardiovascular Imaging2022

Non-invasive imaging as the cornerstone of cardiovascular precision medicine.

Stephan Achenbach, Friedrich Fuchs, Alexandra Goncalves, Claudia Kaiser-Albers, Ziad A Ali, Frank M Bengel, Stefanie Dimmeler, Zahi A Fayad, Alexandre Mebazaa, Benjamin Meder and 5 more

Open access · bronzeAbstract readReview
In one paragraph

Review in European heart journal. Cardiovascular Imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Circumferential strain recovery after human cardiomyocyte transplantation in minipigs using a novel frequency-based method for myocardial tagging quantification.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2026
    Article
  6. Article
  7. Review
  8. Targeting Arterial Dysfunction in Cardiovascular Disease Using Stem Cell-Based Therapies.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. CMR-based cardiac phenotyping in different forms of heart failure.The international journal of cardiovascular imaging · 2024
    Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. The Role of Molecular Imaging in Personalized Medicine.Journal of personalized medicine · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 15 institutions in 6 countries.

Stephan AchenbachDepartment of Cardiology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Universitätsklinikum Erlangen Medizinische Klinik 2-Kardiologie und Angiologie, Ulmenweg 18, 91054 Erlangen, Germany.ORCID 0000-0002-7596-095X
Friedrich FuchsSiemens Healthineers AG, Advanced Therapies, Siemensstraße 1, 91301 Fochheim, Germany.
Alexandra GoncalvesPhilips222 Jacobs Street (5th Floor)Cambridge, MA, 02141, USA.
Claudia Kaiser-AlbersGlobal Clinical Development EMEA, General Medicine, MSD Sharp & Dohme GmbH, Lindenplatz 1, 85540 Haar, HR München B 6194, Germany.
Ziad A AliDeMatteis Cardiovascular Institute, St. Francis Hospital and Heart Center, Cardiovascular Research Foundation, 100 Port Washington Blvd, Roslyn, NY, 11576, USA.
Frank M BengelDepartment of Nuclear Medicine,Hannover Medical School (MHH)Carl-Neuberg-Str. 1,30625 Hannover, Germany.
Stefanie DimmelerInstitute of Cardiovascular Regeneration, Goethe-Universität Frankfurt, Institut für Kardiovaskuläre Regeneration, Zentrum für Molekulare Medizin, Haus 25B, Raum 450, Theodor-Stern-Kai 7, D-60590 Frankfurt, Germany.ORCID 0000-0002-1045-2436
Zahi A FayadThe BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, BioMedical Engineering and Imaging Institute, One Gustave L. Levy Place, Box 1234, New York, NY 10029-6574, USA.ORCID 0000-0002-3439-7347
Alexandre MebazaaUniversité de Paris, Inserm 942 Mascot, APHP, Hôpital Lariboisière, 2 rue Ambroise Paré, 75475 Paris Cedex 10, France.
Benjamin MederInstitute for Cardiomyopathies Heidelberg, Department of Cardiology, Angiology and Pulmology, University Hospital Heidelberg Im Neuenheimer Feld 410, 69120 Heidelberg, Germany.
Jagat NarulaDivision of Cardiology, Mount Sinai Hospital, Mount Sinai Heart, Icahn School of Medicine at Mount Sinai, 421 W. 113th Street, New York, NY, 10021, USA.
Amil ShahDivision of Cardiovascular Medicine, Brigham and Women's Hospital, PBB-116, 75 Francis Street, Boston, MA, 02115, USA.
Sanjay SharmaCardiology clinical and academic group, St George's, University of London, Cranmer Terrace, London SW17 0RE, UK.ORCID 0000-0002-3630-6138
Jens-Uwe VoigtDepartment of Cardiovascular Diseases, University Hospital Leuven, Department of Cardiovascular Sciences, University of Leuven, Herestraat 49, 3060 Leuven, Belgium.
Sven PleinMultidisciplinary Cardiovascular Research Centre (MCRC) and Leeds Institute of Cardiovascular and Metabolic Medicine, Biomedical Imaging Science Department, University of Leeds, Clarendon Way, Leeds LS2 9JT, UK.ORCID 0000-0002-0997-4384
Brigham and Women's Hospital · USFriedrich-Alexander-Universität Erlangen-Nürnberg · DEGoethe University Frankfurt · DEHeidelberg University · DEIcahn School of Medicine at Mount Sinai · USInserm · FRKU Leuven · BEMedizinische Hochschule Hannover · DEMount Sinai Hospital · USMSD (Germany) · DESiemens Healthineers (Germany) · DESt. Francis Hospital · USSt George's, University of London · GBUniversidade do Porto · PTUniversity of Leeds · GB

Funding

Mapping the Progression to HFpEF in the Elderly through Longitudinal Changes in Cardiac FunctionR01HL135008 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI Amil M Shah · 2017 to 2026
$11.5M
British Heart Foundation CH/16/2/32089NHLBI NIH HHS R01 HL135008
6 · The paper itself

Abstract

aimsTo provide an overview of the role of cardiovascular (CV) imaging in facilitating and advancing the field of precision medicine in CV disease. METHODS AND

resultsNon-invasive CV imaging is essential to accurately and efficiently phenotype patients with heart disease, including coronary artery disease (CAD) and heart failure (HF). Various modalities, such as echocardiography, nuclear cardiology, cardiac computed tomography (CT), cardiovascular magnetic resonance (CMR), and invasive coronary angiography, and in some cases a combination, can be required to provide sufficient information for diagnosis and management. Taking CAD as an example, imaging is essential for the detection and functional assessment of coronary stenoses, as well as for the quantification of cardiac function and ischaemic myocardial damage. Furthermore, imaging may detect and quantify coronary atherosclerosis, potentially identify plaques at increased risk of rupture, and guide coronary interventions. In patients with HF, imaging helps identify specific aetiologies, quantify damage, and assess its impact on cardiac function. Imaging plays a central role in individualizing diagnosis and management and to determine the optimal treatment for each patient to increase the likelihood of response and improve patient outcomes.

conclusionsAdvances in all imaging techniques continue to improve accuracy, sensitivity, and standardization of functional and prognostic assessments, and identify established and novel therapeutic targets. Combining imaging with artificial intelligence, machine learning and computer algorithms, as well as with genomic, transcriptomic, proteomic, and metabolomic approaches, will become state of the art in the future to understand pathologies of CAD and HF, and in the development of new, targeted therapies.

Indexed as

Artificial IntelligenceCoronary Artery DiseaseCoronary AngiographyHumansPrecision MedicineProteomicscardiovascular imagingcardiovascular magnetic resonancecoronary computed tomography angiographyechocardiographyheart diseasemolecular imaging

Identifiers

PMID35048106
PMCPMC13376137
OpenAlexW4205126112

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.