Evidence map›Paper›PMID 35048038›Full record

ArticleFrontiers in oral health2021

Serine/Glycine Lipid Recovery in Lipid Extracts From Healthy and Diseased Dental Samples: Relationship to Chronic Periodontitis.

Frank C Nichols, Kruttika Bhuse, Robert B Clark, Anthony A Provatas, Elena Carrington, Yu-Hsiung Wang, Qiang Zhu, Mary E Davey, Floyd E Dewhirst

Open access · goldAbstract read
In one paragraph

Article in Frontiers in oral health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Infection and immunity · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Frank C NicholsDepartment of Oral Health and Diagnostic Sciences, University of Connecticut School of Dental Medicine, Farmington, CT, United States.
Kruttika BhuseDepartment of Oral Health and Diagnostic Sciences, University of Connecticut School of Dental Medicine, Farmington, CT, United States.
Robert B ClarkDepartments of Immunology and Medicine, University of Connecticut School of Medicine, Farmington, CT, United States.
Anthony A ProvatasCenter for Environmental Sciences and Engineering, University of Connecticut, Storrs, CT, United States.
Elena CarringtonDepartment of Oral Health and Diagnostic Sciences, University of Connecticut School of Dental Medicine, Farmington, CT, United States.
Yu-Hsiung WangDepartment of Craniofacial Sciences, University of Connecticut School of Dental Medicine, Farmington, CT, United States.
Qiang ZhuDepartment of Oral Health and Diagnostic Sciences, University of Connecticut School of Dental Medicine, Farmington, CT, United States.
Mary E DaveyDepartment of Oral Biology, University of Florida College of Dentistry, Gainesville, FL, United States.
Floyd E DewhirstDepartment of Microbiology, The Forsyth Institute, Cambridge, MA, United States.
University of Connecticut · USFlorida College · USHarvard University · US

Funding

Mouse Oral Microbiome DatabaseR37DE016937 · NIDCR · ADA FORSYTH INSTITUTE, INC. · PI DEWHIRST, FLOYD E · 2011 to 2020
$8.6M
Cloud-Based Machine Learning and Biomarker Visual Analytics for Salivary ProteomicsR01DE016937 · NIDCR · ADA FORSYTH INSTITUTE, INC. · PI DEWHIRST, FLOYD E, MARK WELCH, JESSICA LEIGH · 2021 to 2025
$6.7M
Regulatory Mechanisms Controlling Expression of P. gingivalis Surface StructuresR01DE019117 · NIDCR · UNIVERSITY OF FLORIDA · PI DAVEY, MARY ELLEN · 2009 to 2019
$4.5M
L-Arg Availability Affects the Physiological State of Porphyromonas gingivalisR01DE024580 · NIDCR · UNIVERSITY OF FLORIDA · PI DAVEY, MARY ELLEN · 2015 to 2024
$3.5M
Porphyromonas gingivalis glycine lipids mediate bone loss through TLR2R01DE027642 · NIDCR · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI NICHOLS, FRANK C · 2019 to 2022
$1.6M
NIDCR NIH HHS R01 DE016937NIDCR NIH HHS R01 DE019117NIDCR NIH HHS R01 DE024580NIDCR NIH HHS R01 DE027642NIDCR NIH HHS R37 DE016937
6 · The paper itself

Abstract

Toll-like receptor 2 (TLR2) activation has been implicated in the pathogenesis of periodontal disease but the identity of the TLR2 agonists has been an evolving story. The serine/glycine lipids produced by

Indexed as

bacterial serine/glycine lipidschronic periodontitisdental tissuesLipid 1256Porphyromona gingivalis

Identifiers

PMID35048038
PMCPMC8757817
OpenAlexW3187019230

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.