Evidence map›Paper›PMID 35047955›Full record

ArticleFrontiers in medical technology2021

Design and Validation of a Multi-Point Injection Technology for MR-Guided Convection Enhanced Delivery in the Brain.

Kayla Prezelski, Megan Keiser, Joel M Stein, Timothy H Lucas, Beverly Davidson, Pedro Gonzalez-Alegre, Flavia Vitale

Abstract read
In one paragraph

Article in Frontiers in medical technology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Design and Characterization of Pressure Monitoring and Insertion system for Intraparenchymal Convection Enhanced Delivery.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2023
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kayla PrezelskiDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA, United States.
Megan KeiserRaymond G. Perelman Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Joel M SteinDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Timothy H LucasCenter for Neuroengineering and Therapeutics, University of Pennsylvania, Philadelphia, PA, United States.
Beverly DavidsonRaymond G. Perelman Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Pedro Gonzalez-AlegreRaymond G. Perelman Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Flavia VitaleDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA, United States.

Funding

A Multipoint Injection Technology for Highly Efficient Convection-Enhanced Delivery of Gene-Based TherapeuticsR01NS117756 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI LUCAS, TIMOTHY H, VITALE, FLAVIA · 2021 to 2023
$1.7M
NINDS NIH HHS R01 NS117756
6 · The paper itself

Abstract

Convection enhanced delivery (CED) allows direct intracranial administration of neuro-therapeutics. Success of CED relies on specific targeting and broad volume distributions (V

Indexed as

convection enhanced deliverydelivery cannulagene therapy and therapeutic deliveryintraparenchymal deliverymicrocannula

Identifiers

PMID35047955
PMCPMC8757778

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.