ArticleFrontiers in medical technology2021
Si-Based Hydrogen-Producing Nanoagent Protects Fetuses From Miscarriage Caused by Mother-to-Child Transmission.
Article in Frontiers in medical technology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Sex differences in placental structure and gene expression in ICR mice during embryonic development.Scientific reports · 2025Article
- Optimum Fermentation Conditions for Bovine Lactoferricin-Lactoferrampin-EncodingFoods (Basel, Switzerland) · 2023Article
- Multi-omics reveal neuroprotection of Acer truncatum Bunge Seed extract on hypoxic-ischemia encephalopathy rats under high-altitude.Communications biology · 2023Article
- Interaction of genetic liability for attention deficit hyperactivity disorder (ADHD) and perinatal inflammation contributes to ADHD symptoms in children.Brain, behavior, & immunity - health · 2023Article
- Diverse Possibilities of Si-Based Agent, a Unique New Antioxidant.Antioxidants (Basel, Switzerland) · 2023Review
- Effect of the new silicon-based agent on the symptoms of interstitial pneumonitis.Scientific reports · 2023Article
- Neuroinflammation and Oxidative Stress in the Pathogenesis of Autism Spectrum Disorder.International journal of molecular sciences · 2023Review
- The development of a novel antioxidant-based antiemetic drug to improve quality of life during anticancer therapy.Biochemistry and biophysics reports · 2022Article
- Prenatal Environment and Neurodevelopmental Disorders.Frontiers in endocrinology · 2022Review
- Prenatal methamphetamine exposure causes dysfunction in glucose metabolism and low birthweight.Frontiers in endocrinology · 2022Article
- Social Communication of Maternal Immune Activation-Affected Offspring Is Improved by Si-Based Hydrogen-Producing Agent.Frontiers in psychiatry · 2022Article
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mother-to-child transmission of viruses and bacteria increases the risk of miscarriage and various diseases in children. Such transmissions can result in infections and diseases in infants or the induction of an inflammatory immune response through the placenta. Recently, we developed a silicon (Si)-based hydrogen-producing nanoagent (Si-based agent) that continuously and effectively produces hydrogen in the body. Since medical hydrogen has antioxidative, anti-inflammatory, antiallergic, and antiapoptotic effects, we investigated the effects of our Si-based agent on mother-to-child transmission, with a focus on the rate of miscarriage. In pregnant mice fed a diet containing the Si-based agent, lipopolysaccharide (LPS)-induced miscarriage due to mother-to-child transmission was reduced and inflammation and neutrophil infiltration in the placenta were suppressed. We also found that the Si-based agent suppressed IL-6 expression in the placenta and induced the expression of antioxidant and antiapoptotic genes, such as
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