Evidence map›Paper›PMID 35047878›Full record

ReviewFrontiers in medical technology2020

Harnessing Recent Advances in Synthetic DNA and Electroporation Technologies for Rapid Vaccine Development Against COVID-19 and Other Emerging Infectious Diseases.

Ziyang Xu, Ami Patel, Nicholas J Tursi, Xizhou Zhu, Kar Muthumani, Daniel W Kulp, David B Weiner

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in medical technology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

  1. Pooled it
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  16. mRNA Vaccines to Protect Against Diseases.Methods in molecular biology (Clifton, N.J.) · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Ziyang XuThe Vaccine and Immunotherapy Center, Wistar Institute, Philadelphia, PA, United States.
Ami PatelThe Vaccine and Immunotherapy Center, Wistar Institute, Philadelphia, PA, United States.
Nicholas J TursiThe Vaccine and Immunotherapy Center, Wistar Institute, Philadelphia, PA, United States.
Xizhou ZhuThe Vaccine and Immunotherapy Center, Wistar Institute, Philadelphia, PA, United States.
Kar MuthumaniThe Vaccine and Immunotherapy Center, Wistar Institute, Philadelphia, PA, United States.
Daniel W KulpThe Vaccine and Immunotherapy Center, Wistar Institute, Philadelphia, PA, United States.
David B WeinerThe Vaccine and Immunotherapy Center, Wistar Institute, Philadelphia, PA, United States.
The Wistar Institute · USUniversity of Pennsylvania · US

Funding

COLLABORATIVE INFLUENZA VACCINE INNOVATION CENTER: UNIVERSAL INFLUENZA VACCINE RESEARCH75N93019C00051 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KRAMMER, FLORIAN · 2019 to 2025
$105.4M
NIAID NIH HHS 75N93019C00051
6 · The paper itself

Abstract

DNA vaccines are considered as a third-generation vaccination approach in which antigenic materials are encoded as DNA plasmids for direct

Indexed as

coronavirusesCOVID-19DNA-launched nanoparticle vaccinesDNA vaccinesemerging infectious diseases (EIDs)intradermal electroporationintranasal vaccinesSARS-CoV-2

Identifiers

PMID35047878
PMCPMC8757735
OpenAlexW3094207847

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.