ArticleBMJ surgery, interventions, & health technologies2021
Meta-analysis with individual data of functional outcomes following Aquablation for lower urinary tract symptoms due to BPH in various prostate anatomies.
Article in BMJ surgery, interventions, & health technologies, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- Review
- Aquablation/AquaBeam Waterjet Therapy for Benign Prostatic Hyperplasia: Three-Year Functional and Ejaculatory Outcomes in a Multicenter Real-World Italian Cohort.Lower urinary tract symptoms · 2026Article
- The learning curve of waterjet ablation of the prostate: a cumulative sum analysis of surgical and functional outcomes.World journal of urology · 2026Article
- Management of lower urinary tract symptoms before prostate cancer radiotherapy: a call for innovative strategies.World journal of urology · 2026Review
- Aquablation versus AEEP for BPH: technique, outcomes, and the evolving surgical landscape - an EAU endourology perspective.World journal of urology · 2026Review
- Aquablation for benign prostatic hyperplasia: real-world prostate size relevance and bleeding events across 6 years.BJU international · 2026Article
- Investigation on the cutting-infiltration integrated strategy based on medical waterjet for targeted drug delivery.Scientific reports · 2026Article
- Cost Considerations in Penile Implant Surgery from a Global Perspective.Current urology reports · 2026Review
- Management and Treatment of Benign Prostatic Hyperplasia Symptoms: Current Insights.Research and reports in urology · 2025Review
- Aquablation Therapy in Large Prostates (80-150 mL) for Lower Urinary Tract Symptoms Due to Benign Prostatic Hyperplasia: Final WATER II 5-Year Clinical Trial Results.The Journal of urology · 2023Article
Corrections and comments
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Authors and funding
12 authors at 11 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo evaluate functional outcomes following Aquablation in various prostate volume and anatomical subgroups.
designA meta-analysis with individual patient data undergoing Aquablation therapy from four prospective, global, clinical studies that have been conducted with Aquablation; WATER, WATER II, FRANCAIS WATER and OPEN WATER.
settingAustralia, Canada, Lebanon, Germany, New Zealand, UK and the USA.
participants425 men with lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH) with 1-year follow-up.
interventionsAquablation therapy is an ultrasound guided, robotically executed waterjet ablative procedure for the prostate.
main outcome measuresThe analyses focus International Prostate Symptom Score (IPSS), uroflowmetry, postoperative Incontinence Severity Index (ISI) and surgical retreatment.
results425 men with prostates ranging in size from 20 to 150 mL underwent Aquablation therapy. The outcomes from the seven questions in the IPSS questionnaire were grouped by the following; prostates <100 mL, prostates ≥100 mL, prostate anatomy with an obstructive median lobe identifed by imaging, and prostate anatomy without an obstructive median lobe. Regardless of subgroup, all outcomes are consistent and demonstrate a significant improvement from baseline. Specifically, improvements in frequency, urgency and nocturia demonstrated bladder function improvement. Patients entering treatment with severe incontinence, ISI score >4, and regardless of prostate size, showed a reduction in incontinence during patient follow-up. Surgical retreatment due to BPH symptoms occurred in 0.7% (95% CI 0.1%-2.0%).
conclusionsAcross a variety of prostate anatomies, Aquablation therapy showed remarkable functional improvements following the index procedure. Additionally, men with moderate to severe LUTS/BPH and overactive bladder resulting in urge incontinence showed a reduction in incontinence symptoms postprocedure.
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