Evidence map›Paper›PMID 35047507›Full record

ArticleFrontiers in cell and developmental biology2021

The Establishment of Quantitatively Regulating Expression Cassette with sgRNA Targeting

Changping Deng, Fabiao Hu, Zhangting Zhao, Yiwen Zhou, Yuping Liu, Tong Zhang, Shihui Li, Wenyun Zheng, Wenliang Zhang, Tianwen Wang and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Changping DengState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China.
Fabiao HuState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China.
Zhangting ZhaoState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China.
Yiwen ZhouState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China.
Yuping LiuShanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, China.
Tong ZhangShanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, China.
Shihui LiState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China.
Wenyun ZhengShanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, China.
Wenliang ZhangCenter of Translational Biomedical Research, University of North Carolina at Greensboro, Greensboro, NC, United States.
Tianwen WangCollege of Life Sciences, Xinyang Normal University, Xinyang, China.
Xingyuan MaState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China.
East China University of Science and Technology · CNUniversity of North Carolina at Greensboro · USXinyang Normal University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Quantitative analysis and regulating gene expression in cancer cells is an innovative method to study key genes in tumors, which conduces to analyze the biological function of the specific gene. In this study, we found the expression levels of Survivin protein (

Indexed as

CRISPR/Cas9-based Tet-off systemMCF-7 cellsmulti-drug resistanceP-GlycoproteinPI3K/Akt/mTOR pathwaysurvivin

Identifiers

PMID35047507
PMCPMC8762277
OpenAlexW4205252590

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.