ArticleFrontiers in public health2021
Regressing SARS-CoV-2 Sewage Measurements Onto COVID-19 Burden in the Population: A Proof-of-Concept for Quantitative Environmental Surveillance.
Article in Frontiers in public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers, 1 of them a synthesis that pooled it.
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Who cites it
87 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Recent progress on wastewater-based epidemiology for COVID-19 surveillance: A systematic review of analytical procedures and epidemiological modeling.The Science of the total environment · 2023Pooled it
- Comparative Efficiency of High-Throughput Magnetic Bead Method and Polyethylene Glycol Precipitation for Viral Concentration in Sewage.Food and environmental virology · 2025Article
- Portable DNA extraction integrated with LAMP-CRISPR/Cas12a technology for on-site detection of Salmonella Typhimurium.NPJ science of food · 2025Article
- Detection of biological loads in sewage using the automated robot-driven photoelectrochemical biosensing platform.Exploration (Beijing, China) · 2024Article
- Inter-institutional laboratory standardization for SARS-CoV-2 surveillance through wastewater-based epidemiology applied to Mexico City.IJID regions · 2024Article
- Analytical validation of a semi-automated methodology for quantitative measurement of SARS-CoV-2 RNA in wastewater collected in northern New England.Microbiology spectrum · 2024Article
- Development of an early alert model for pandemic situations in Germany.Scientific reports · 2023Article
- Optimizing campus-wide COVID-19 test notifications with interpretable wastewater time-series features using machine learning models.Scientific reports · 2023Article
- Strategies for safe management of hospital wastewater during the COVID-19 pandemic.International journal of environmental science and technology : IJEST · 2023Review
- Municipal wastewater viral pollution in Saudi Arabia: effect of hot climate on COVID-19 disease spreading.Environmental science and pollution research international · 2023Article
- A systematic review on the occurrence, fate, and remediation of SARS-CoV-2 in wastewater.International journal of environmental science and technology : IJEST · 2023Review
- SARS-CoV-2 Burden in Wastewater and its Elimination Using Disinfection.Microbiology insights · 2023Review
- Evaluation of SARS-CoV-2 RNA Presence in Treated and Untreated Hospital Sewage.Water, air, and soil pollution · 2023Article
- Comparison of the methods for isolation and detection of SARS-CoV-2 RNA in municipal wastewater.Frontiers in public health · 2023Article
- SARS-CoV-2 infection dynamics revealed by wastewater sequencing analysis and deconvolution.The Science of the total environment · 2022Article
- Understanding the dynamic relation between wastewater SARS-CoV-2 signal and clinical metrics throughout the pandemic.The Science of the total environment · 2022Article
- Importance of wastewater-based epidemiology for detecting and monitoring SARS-CoV-2.Case studies in chemical and environmental engineering · 2022Article
- Multifaceted Assessment of Wastewater-Based Epidemiology for SARS-CoV-2 in Selected Urban Communities in Davao City, Philippines: A Pilot Study.International journal of environmental research and public health · 2022Article
- A Review of the Presence of SARS-CoV-2 in Wastewater: Transmission Risks in Mexico.International journal of environmental research and public health · 2022Review
- Development of an efficient wastewater testing protocol for high-throughput country-wide SARS-CoV-2 monitoring.The Science of the total environment · 2022Article
27 more citing papers are in PubMed but not listed here.
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Authors and funding
22 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an RNA virus, a member of the coronavirus family of respiratory viruses that includes severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1) and the Middle East respiratory syndrome (MERS). It has had an acute and dramatic impact on health care systems, economies, and societies of affected countries during the past 8 months. Widespread testing and tracing efforts are being employed in many countries in attempts to contain and mitigate this pandemic. Recent data has indicated that fecal shedding of SARS-CoV-2 is common and that the virus RNA can be detected in wastewater. This indicates that wastewater monitoring may provide a potentially efficient tool for the epidemiological surveillance of SARS-CoV-2 infection in large populations at relevant scales. In particular, this provides important means of (i) estimating the extent of outbreaks and their spatial distributions, based primarily on in-sewer measurements, (ii) managing the early-warning system quantitatively and efficiently, and (iii) verifying disease elimination. Here we report different virus concentration methods using polyethylene glycol (PEG), alum, or filtration techniques as well as different RNA extraction methodologies, providing important insights regarding the detection of SARS-CoV-2 RNA in sewage. Virus RNA particles were detected in wastewater in several geographic locations in Israel. In addition, a correlation of virus RNA concentration to morbidity was detected in Bnei-Barak city during April 2020. This study presents a proof of concept for the use of direct raw sewage-associated virus data, during the pandemic in the country as a potential epidemiological tool.
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