Evidence map›Paper›PMID 35047127›Full record

ArticleOncotarget2022

Suppressive GLI2 fragment enhances liver metastasis in colorectal cancer.

Ruiko Ogata, Shiori Mori, Hitoshi Ohmori, Shingo Kishi, Rina Fujiwara-Tani, Takamitsu Sasaki, Yukiko Nishiguchi, Chie Nakashima, Kei Goto, Isao Kawahara and 2 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 2 countries.

Ruiko OgataDepartment of Molecular Pathology, Nara Medical University, Kashihara, Nara 634-8521, Japan.
Shiori MoriDepartment of Molecular Pathology, Nara Medical University, Kashihara, Nara 634-8521, Japan.
Hitoshi OhmoriDepartment of Molecular Pathology, Nara Medical University, Kashihara, Nara 634-8521, Japan.
Shingo KishiDepartment of Molecular Pathology, Nara Medical University, Kashihara, Nara 634-8521, Japan.
Rina Fujiwara-TaniDepartment of Molecular Pathology, Nara Medical University, Kashihara, Nara 634-8521, Japan.
Takamitsu SasakiDepartment of Molecular Pathology, Nara Medical University, Kashihara, Nara 634-8521, Japan.
Yukiko NishiguchiDepartment of Molecular Pathology, Nara Medical University, Kashihara, Nara 634-8521, Japan.
Chie NakashimaDepartment of Molecular Pathology, Nara Medical University, Kashihara, Nara 634-8521, Japan.
Kei GotoDepartment of Molecular Pathology, Nara Medical University, Kashihara, Nara 634-8521, Japan.
Isao KawaharaDepartment of Molecular Pathology, Nara Medical University, Kashihara, Nara 634-8521, Japan.
Yi LuoKey Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu Province 226001, China.
Hiroki KuniyasuDepartment of Molecular Pathology, Nara Medical University, Kashihara, Nara 634-8521, Japan.
Nara Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Linoleic acid (LA) has been shown to cause inflammation and promote development of colorectal cancer (CRC). Moreover, many literatures show that LA is associated with cancer metastasis. Metastatic cancer cells have high stemness, suggesting that LA might affect the stemness of cancer cells. In this study, we examined the effect of LA on the hedgehog system, which affects cancer stemness. In CT26 cells, LA treatment induced the expression of sonic hedgehog

Indexed as

Colorectal NeoplasmsLiver NeoplasmsAnimalsHedgehog ProteinsHumansKruppel-Like Transcription FactorsLinoleic AcidMiceNuclear ProteinsTranscription FactorsZinc Finger Protein Gli2GLI2 protein, humanHedgehog ProteinsKruppel-Like Transcription FactorsLinoleic AcidNuclear ProteinsTranscription FactorsZinc Finger Protein Gli2colorectal cancerGLI2linoleic acidstemnessubiquitination

Identifiers

PMID35047127
PMCPMC8763325
OpenAlexW4205650308

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.