Evidence map›Paper›PMID 35046946›Full record

ReviewFrontiers in immunology2021

Natural Barcodes for Longitudinal Single Cell Tracking of Leukemic and Immune Cell Dynamics.

Livius Penter, Satyen H Gohil, Catherine J Wu

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 3 countries.

Livius PenterDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, United States.
Satyen H GohilDepartment of Academic Haematology, University College London Cancer Institute, London, United Kingdom.
Catherine J WuDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, United States.
Brigham and Women's Hospital · USDana-Farber Cancer Institute · USLondon Cancer · GB

Funding

Cancer Immune Monitoring and Analysis CenterU24CA224331 · NCI · DANA-FARBER CANCER INST · PI FRANK S HODI, Catherine Ju-Ying Wu · 2017 to 2026
$18.4M
Single Cell and ImmunogenomicsP01CA229092 · NCI · DANA-FARBER CANCER INST · PI RITZ, JEROME · 2019 to 2023
$13.8M
Personal tumor neoantigens for immunity against chronic lymphocytic leukemiaR01CA155010 · NCI · DANA-FARBER CANCER INST · PI Catherine Ju-Ying Wu · 2011 to 2026
$9.6M
ITSC for Leukemia: Novel Molecular strategies for NCTN "Individualized" TherapiesUG1CA233338 · NCI · UNIVERSITY OF CINCINNATI · PI BYRD, JOHN C. · 2019 to 2025
$4.5M
(PQ8) Genetically faithful murine models for studying disease progression in chronic lymphocytic leukemiaR01CA216273 · NCI · DANA-FARBER CANCER INST · PI WANG, LILI, WU, CATHERINE JU-YING · 2017 to 2021
$3.5M
NCI NIH HHS P01 CA229092NCI NIH HHS R01 CA155010NCI NIH HHS R01 CA216273NCI NIH HHS U24 CA224331NCI NIH HHS UG1 CA233338
6 · The paper itself

Abstract

Blood malignancies provide unique opportunities for longitudinal tracking of disease evolution following therapeutic bottlenecks and for the monitoring of changes in anti-tumor immunity. The expanding development of multi-modal single-cell sequencing technologies affords newer platforms to elucidate the mechanisms underlying these processes at unprecedented resolution. Furthermore, the identification of molecular events that can serve as

Indexed as

LeukemiaCell LineageCell TrackingDNA Barcoding, TaxonomicHumansImmunophenotypingSingle-Cell Analysisallogeneic hematopoietic stem cell transplantation (allo-HCT)B cell receptor sequencecopy number variants (CNV)mitochondrial DNA mutationsingle-cell sequencingsingle nucleotide polymorphismsomatic nuclear mutationT cell receptor sequence

Identifiers

PMID35046946
PMCPMC8761982
OpenAlexW4206106410

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.