Evidence map›Paper›PMID 35046945›Full record

ReviewFrontiers in immunology2021

Application of Machine Learning for Cytometry Data.

Zicheng Hu, Sanchita Bhattacharya, Atul J Butte

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Zicheng HuBakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA, United States.
Sanchita BhattacharyaBakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA, United States.
Atul J ButteBakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA, United States.

Funding

Pan-vaccine Analysis to Test the Impact of Cytomegalovirus on Vaccine EfficacyUH2AI153016 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HU, ZICHENG · 2020 to 2021
$444k
NIAID NIH HHS UH2 AI153016NIH HHS HHSN316201200036W
6 · The paper itself

Abstract

Modern cytometry technologies present opportunities to profile the immune system at a single-cell resolution with more than 50 protein markers, and have been widely used in both research and clinical settings. The number of publicly available cytometry datasets is growing. However, the analysis of cytometry data remains a bottleneck due to its high dimensionality, large cell numbers, and heterogeneity between datasets. Machine learning techniques are well suited to analyze complex cytometry data and have been used in multiple facets of cytometry data analysis, including dimensionality reduction, cell population identification, and sample classification. Here, we review the existing machine learning applications for analyzing cytometry data and highlight the importance of publicly available cytometry data that enable researchers to develop and validate machine learning methods.

Indexed as

Machine LearningAnimalsFlow CytometryHumanscyTOFcytometryflow cytometrymachine learningpredictive modeling

Identifiers

PMID35046945
PMCPMC8761933

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.