Evidence map›Paper›PMID 35046936›Full record

ReviewFrontiers in immunology2021

Revisiting the Development of Vaccines Against Pathogenic

Giovana C Barazzone, Aline F Teixeira, Bruna O P Azevedo, Deborah K Damiano, Marcos P Oliveira, Ana L T O Nascimento, Alexandre P Y Lopes

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Application of FT-IR spectroscopy using the IR BiotyperEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Advances in the development of a vaccine for the prevention of human leptospirosis: a review.Revista do Instituto de Medicina Tropical de Sao Paulo · 2026
    Review
  8. Review
  9. Review
  10. Leptospirosis.Nature reviews. Disease primers · 2025
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Exposure to live saprophyticbioRxiv : the preprint server for biology · 2024
    Article
  18. Genetic structure and diversity of theLife science alliance · 2024
    Article
  19. Article
  20. Vaccines · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Giovana C BarazzoneLaboratório de Desenvolvimento de Vacinas, Instituto Butantan, São Paulo, Brazil.
Aline F TeixeiraLaboratório de Desenvolvimento de Vacinas, Instituto Butantan, São Paulo, Brazil.
Bruna O P AzevedoLaboratório de Desenvolvimento de Vacinas, Instituto Butantan, São Paulo, Brazil.
Deborah K DamianoLaboratório de Desenvolvimento de Vacinas, Instituto Butantan, São Paulo, Brazil.
Marcos P OliveiraLaboratório de Desenvolvimento de Vacinas, Instituto Butantan, São Paulo, Brazil.
Ana L T O NascimentoLaboratório de Desenvolvimento de Vacinas, Instituto Butantan, São Paulo, Brazil.
Alexandre P Y LopesLaboratório de Desenvolvimento de Vacinas, Instituto Butantan, São Paulo, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human vaccination against leptospirosis has been relatively unsuccessful in clinical applications despite an expressive amount of vaccine candidates has been tested over years of research. Pathogenic

Indexed as

Vaccine DevelopmentBacterial VaccinesHumansLeptospiraLeptospirosisBacterial Vaccinesdevelopment of vaccinehuman leptospirosis vaccineLeptospiraleptospirosisvaccine

Identifiers

PMID35046936
PMCPMC8761801

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.