Evidence map›Paper›PMID 35046926›Full record

ArticleFrontiers in microbiology2021

Robust Heat Shock Response in

Yehong Huang, Wurihan Wurihan, Bin Lu, Yi Zou, Yuxuan Wang, Korri Weldon, Joseph D Fondell, Zhao Lai, Xiang Wu, Huizhou Fan

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.9field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
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  3. Coordinated topoisomerase function shapes the fluoroquinolone response ofbioRxiv : the preprint server for biology · 2026
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  8. Tail-specific protease is an essentialInfection and immunity · 2024
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  10. Expression activation of over 70% ofInfection and immunity · 2024
    Article
  11. Article
  12. Review
  13. Article
  14. Requirement of GrgA forbioRxiv : the preprint server for biology · 2023
    Article
  15. Article
  16. Plasmid-mediated virulence inFrontiers in cellular and infection microbiology · 2023
    Review
  17. Molecular pathogenesis ofFrontiers in cellular and infection microbiology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Yehong HuangDepartment of Parasitology, Xiangya School of Basic Medicine, Central South University, Changsha, China.
Wurihan WurihanDepartment of Pharmacology, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ, United States.
Bin LuDepartment of Parasitology, Xiangya School of Basic Medicine, Central South University, Changsha, China.
Yi ZouGreehey Children's Cancer Research Institute, University of Texas Health San Antonio, San Antonio, TX, United States.
Yuxuan WangDepartment of Pharmacology, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ, United States.
Korri WeldonGreehey Children's Cancer Research Institute, University of Texas Health San Antonio, San Antonio, TX, United States.
Joseph D FondellDepartment of Pharmacology, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ, United States.
Zhao LaiGreehey Children's Cancer Research Institute, University of Texas Health San Antonio, San Antonio, TX, United States.
Xiang WuDepartment of Parasitology, Xiangya School of Basic Medicine, Central South University, Changsha, China.
Huizhou FanDepartment of Pharmacology, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ, United States.
Johnson University · USThe University of Texas Health Science Center at San Antonio · USCentral South University · CNRutgers, The State University of New Jersey · USThe University of Texas at San Antonio · US

Funding

TISSUE CULTURE---COREP30CA054174 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Robin Jean Leach · 1991 to 2026
$59.1M
High Throughput DNA Sequencer: Illumina HiSeq 3000 SequencerS10OD021805 · OD · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI LAI, ZHAO · 2016 to 2016
$600k
GrgA:a Multifunctional Transcription Factor that Control Chlamydial Gene ExpressionR21AI140167 · NIAID · RBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL · PI FAN, HUIZHOU · 2019 to 2020
$435k
Exploration of SF3 as a Chemical Probe for Chlamydial BiologyR21AI154305 · NIAID · RBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL · PI FAN, HUIZHOU · 2020 to 2021
$431k
NCI NIH HHS P30 CA054174NIAID NIH HHS R21 AI140167NIAID NIH HHS R21 AI154305NIH HHS S10 OD021805
6 · The paper itself

Abstract

Cells reprogram their transcriptome in response to stress, such as heat shock. In free-living bacteria, the transcriptomic reprogramming is mediated by increased DNA-binding activity of heat shock sigma factors and activation of genes normally repressed by heat-induced transcription factors. In this study, we performed transcriptomic analyses to investigate heat shock response in the obligate intracellular bacterium

Indexed as

Chlamydiaheat-induced transcription repressorheat shock responseHrcAsigma factorstress responsetranscriptional regulatory networktranscriptome

Identifiers

PMID35046926
PMCPMC8762339
OpenAlexW4206031702

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.