Evidence map›Paper›PMID 35046899›Full record

ArticleFrontiers in endocrinology2021

A Novel Tree Shrew Model of Diabetic Retinopathy.

Oleg S Gorbatyuk, Priyamvada M Pitale, Irina V Saltykova, Iuliia B Dorofeeva, Assylbek A Zhylkibayev, Mohammad Athar, Preston A Fuchs, Brian C Samuels, Marina S Gorbatyuk

Open access · goldAbstract read
In one paragraph

Article in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 20 citations in OpenAlex.

  1. Measuring electroretinograms in tree shrews with a portable electrophysiology device.Documenta ophthalmologica. Advances in ophthalmology · 2026
    Article
  2. Type 2 Diabetes Mellitus in the Northern Tree Shrew (Tupaia belangeri).Journal of the American Association for Laboratory Animal Science : JAALAS · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Unexpected Retinal Abnormalities in the Cone-Dominant Northern Tree Shrew.Advances in experimental medicine and biology · 2025
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Proteomic analysis of diabetic retinas.Frontiers in endocrinology · 2023
    Article
  15. Posttranslational modifications of proteins in diseased retina.Frontiers in cellular neuroscience · 2023
    Review
  16. Diabetic Retinopathy: From Animal Models to Cellular Signaling.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Oleg S GorbatyukDepartment of Optometry and Vision Science, School of Optometry, University of Alabama at Birmingham, Birmingham, AL, United States.
Priyamvada M PitaleDepartment of Optometry and Vision Science, School of Optometry, University of Alabama at Birmingham, Birmingham, AL, United States.
Irina V SaltykovaDepartment of Optometry and Vision Science, School of Optometry, University of Alabama at Birmingham, Birmingham, AL, United States.
Iuliia B DorofeevaDepartment of Optometry and Vision Science, School of Optometry, University of Alabama at Birmingham, Birmingham, AL, United States.
Assylbek A ZhylkibayevDepartment of Optometry and Vision Science, School of Optometry, University of Alabama at Birmingham, Birmingham, AL, United States.
Mohammad AtharDepartment of Dermatology, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.
Preston A FuchsDepartment of Ophthalmology and Visual Sciences, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.
Brian C SamuelsDepartment of Ophthalmology and Visual Sciences, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.
Marina S GorbatyukDepartment of Optometry and Vision Science, School of Optometry, University of Alabama at Birmingham, Birmingham, AL, United States.
University of Alabama at Birmingham · US

Funding

University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BARBARA A GOWER · 2013 to 2026
$19.5M
Visual Phenotyping CoreP30EY003039 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Paul Douglas Gamlin · 1985 to 2026
$16.9M
Post-translational histone modification in ocular tissues of mice exposed to arsenicalsR01EY027763 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GORBATYUK, MARINA · 2018 to 2022
$2.0M
Development and Validation of a Tree Shrew Model of Diabetic RetinopathyR21EY031103 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GORBATYUK, MARINA · 2019 to 2019
$297k
NEI NIH HHS P30 EY003039NEI NIH HHS R01 EY027763NEI NIH HHS R21 EY031103NIDDK NIH HHS P30 DK079626
6 · The paper itself

Abstract

Existing animal models with rod-dominant retinas have shown that hyperglycemia injures neurons, but it is not yet clearly understood how blue cone photoreceptors and retinal ganglion cells (RGCs) deteriorate in patients because of compromised insulin tolerance. In contrast, northern tree shrews (

Indexed as

Disease Models, AnimalAnimalsDiabetic RetinopathyElectroretinographyHyperglycemiaMaleSignal TransductionTupaiidaediabetesdiabetic conediabetic retinopathyp-AKT/p-mTOR axisretinal ganglion cellstree shrews

Identifiers

PMID35046899
PMCPMC8762304
OpenAlexW4206118590

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.